NCT03584945

Task Control Circuit Targets for Obsessive Compulsive Behaviors in Children

Completed NA Last updated 13 February 2025

What this trial tests

NA trial testing Cognitive Behavioral Therapy in Obsessive-compulsive Disorders and Symptoms in Children in 169 participants. Completed in 3 June 2023.

Timeline

24 March 2019

Primary endpoint
3 June 2023

3 June 2023

Quick facts

Lead sponsor	University of Michigan
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	169
Start date	24 March 2019
Primary completion	3 June 2023
Estimated completion	3 June 2023
Sites	2 locations across United States

Drugs / interventions tested

• Cognitive Behavioral Therapy
• Community Referral as appropriate

Conditions studied

• Obsessive-compulsive Disorders and Symptoms in Children — all drugs for Obsessive-compulsive Disorders and Symptoms in Children →

Sponsor

University of Michigan

Who can join

Adults 6 to 14, any sex, with Obsessive-compulsive Disorders and Symptoms in Children. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study will use magnetic resonance imaging (MRI) to assess the function and structure of overlapping task control circuits in children with a range of Obsessive-Compulsive symptoms (OCS). The functioning of task control circuits will be assessed using the well-validated Multisource interference task (MSIT). This study will also assess functional and anatomical connectivity within task control circuits in the same children, and determine whether disturbances in these overlapping circuits are associated with Obsessive-Compulsive Disorder (OCD) symptom severity. Behavioral measures will be administered to further assess regulatory, learning and memory functions. Children with OCD will then be offered a standard course of up to 12 cognitive behavioral therapy (CBT), either via remote video conference sessions or in person visits when clinically indicated, before scanning (along with age-and gender-matched control participants) in order to assess how these circuits may change with treatment. Children with subclinical OC symptoms will be offered referral for treatment on an as-needed basis. In addition, de-identified data may be used in the future to conduct secondary data analyses. As more about OC symptoms and neurobiological mechanisms of interest in the current study are understood, data may be used to answer questions beyond those described in this protocol. All study procedures will be conducted on-site at Columbia University/the New York State Psychiatric Institute (New York, NY) and the University of Michigan's outpatient Child and Adolescent Psychiatry (Ann Arbor, Michigan).

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

1. Probing midbrain dopamine function in pediatric obsessive-compulsive disorder via neuromelanin-sensitive magnetic resonance imaging.
   Pagliaccio D, Wengler K, Durham K, Fontaine M, et al · · 2023 · cited 12× · PMID 37198261 · DOI 10.1038/s41380-023-02105-z
2. Hereditary Patterns and Genetic Associations in Obsessive-Compulsive Disorder (OCD): Neuropsychiatric Insights, Genetic Influences, and Treatment Perspectives.
   Dhiman A, Mehan S, Khan Z, Tiwari A, et al · · 2025 · cited 4× · PMID 39219434 · DOI 10.2174/0115665232316708240828063527
3. Subcortical shape in pediatric and adult obsessive-compulsive disorder.
   Wang Z, Fontaine M, Cyr M, Rynn MA, et al · · 2022 · cited 4× · PMID 35485920 · DOI 10.1002/da.23261