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NCT03584204: SLIM
Skeletal Muscle Parameters of Liver Cirrhosis in Non-invasive Imaging and Outcome
trial testing imaging in Liver Cirrhosis in 400 participants. Currently enrolling.
31 July 2025
Quick facts
| Lead sponsor | University Hospital, Bonn |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 400 |
| Start date | 1 January 2018 |
| Primary completion | 31 July 2025 |
| Estimated completion | 31 August 2026 |
| Sites | 3 locations across Italy, Germany |
Drugs / interventions tested
- imaging
Conditions studied
- Liver Cirrhosis — all drugs for Liver Cirrhosis →
Sponsor
University Hospital, Bonn
Who can join
Adults 18 to 80, any sex, with Liver Cirrhosis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The principal aim of this study is to analyse L3-SMI (skeletal muscle index) in a cohort of patients with decompensated liver cirrhosis and TIPS (transjugular intrahepatic portosystemic shunt), and compare the prognostic power with TPMT (transverse psoas muscle thickness). Furthermore, the role of myosteatosis, determined in CT by L3-SMI, MRI and ultrasound will be studied.
Publications & conference data
5 peer-reviewed publications reference this trial (live from Europe PMC):
-
Sarcopenia Is Associated With Development of Acute-on-Chronic Liver Failure in Decompensated Liver Cirrhosis Receiving Transjugular Intrahepatic Portosystemic Shunt.
Praktiknjo M, Clees C, Pigliacelli A, Fischer S, et al · · 2019 · cited 95× · PMID 30939488 · DOI 10.14309/ctg.0000000000000025 -
Combination of Fat-Free Muscle Index and Total Spontaneous Portosystemic Shunt Area Identifies High-Risk Cirrhosis Patients.
Faron A, Abu-Omar J, Chang J, Böhling N, et al · · 2022 · cited 9× · PMID 35492329 · DOI 10.3389/fmed.2022.831005 -
Ultrasound-Defined Sarcopenia Independently Predicts Acute Decompensation in Advanced Chronic Liver Disease.
Gödiker J, Schwind L, Jacob T, Böhling N, et al · · 2024 · cited 8× · PMID 39529225 · DOI 10.1002/jcsm.13630 -
Myosteatosis independently predicts transplant-free survival in patients with primary sclerosing cholangitis.
Praktiknjo M, Zhou T, Krüsken M, Jacob T, et al · · 2023 · cited 6× · PMID 37586906 · DOI 10.1016/j.dld.2023.08.037 -
Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis.
Queck A, Thomas D, Jansen C, Schreiber Y, et al · · 2019 · cited 6× · PMID 31644538 · DOI 10.1371/journal.pone.0222840
Verify or expand the search:
- PubMed search for NCT03584204
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other University Hospital, Bonn trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03584204 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Bonn
- Last refreshed: 5 October 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03584204.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing