Last reviewed · How we verify
The Long-Term Safety of Budesonide for Patients With Chronic Rhinosinusitis
Chronic Rhinosinusitis (CRS) is a common disorder of the nose. The current practice at St Paul's Sinus Centre is to prescribe budesonide via the mucosal atomization device or impregnated saline irrigation. Both have shown to be a safe method of administration. A previous study demonstrated a 6% elevation in intraocular pressure and 3% prevalence of asymptomatic AdrenoCorticoTropic Hormone-Axis (ACTH) suppression. However, a baseline measurement was not conducted to ascertain the correlation of these findings with the medication. Therefore, the investigators aim to conduct baseline measurements of IntraOcular Pressure (IOP), ACTH-axis function, and Dual Energy X-ray Absorptiometry (DEXA) scan and obtaining regular measurements of these variables within a 12-month period to further ascertain these previous findings.
Details
| Lead sponsor | St. Paul's Hospital, Canada |
|---|---|
| Phase | NA |
| Status | UNKNOWN |
| Enrolment | 100 |
| Start date | Wed Sep 05 2018 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Sat Dec 25 2021 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Sinusitis
Interventions
- Budesonide via MAD device
- Budesonide via intranasals Saline Irrigation
Countries
Canada