NCT03578614 (AFIVASC) is a NA clinical trial of Physical Activity in Vascular Cognitive Impairment, sponsored by Instituto de Medicina Molecular João Lobo Antunes.

Who is sponsoring NCT03578614?

NCT03578614 is sponsored by Instituto de Medicina Molecular João Lobo Antunes.

What drugs are being tested in NCT03578614?

Interventions in NCT03578614: Physical Activity.

What condition does NCT03578614 study?

NCT03578614 studies Vascular Cognitive Impairment.

Is NCT03578614 still recruiting?

NCT03578614 is currently completed. Last updated 1 April 2021.

Last reviewed 2021-04-01 · How we verify

NCT03578614: AFIVASC

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Impact of Physical Activity in Vascular Cognitive Impairment ( AFIVASC )

Completed NA Last updated 1 April 2021

What this trial tests

NA trial testing Physical Activity in Vascular Cognitive Impairment in 104 participants. Completed in 30 June 2020.

Timeline

1 September 2016

Primary endpoint
31 December 2019

30 June 2020

Quick facts

Lead sponsor	Instituto de Medicina Molecular João Lobo Antunes
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	104
Start date	1 September 2016
Primary completion	31 December 2019
Estimated completion	30 June 2020
Sites	1 location across Portugal

Drugs / interventions tested

Physical Activity

Conditions studied

Vascular Cognitive Impairment — all drugs for Vascular Cognitive Impairment →

Sponsor

Instituto de Medicina Molecular João Lobo Antunes — full company profile →

Who can join

18 and older, any sex, with Vascular Cognitive Impairment. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Vascular cognitive impairment (VCI) is one of the most frequent causes of cognitive impairment associated with aging. So far, there is no approved treatment for VCI. Recent studies have suggested a protective effect from physical activity but adequate studies are lacking in this field. The AFIVASC study - a Portuguese acronym for "physical activity in vascular cognitive impairment" is a randomized controlled study, single-blinded, nonpharmacological which aims to explore the benefits of physical activity in vascular cognitive impairment (VCI)

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

European Stroke Organisation and European Academy of Neurology joint guidelines on post-stroke cognitive impairment.
Quinn TJ, Richard E, Teuschl Y, Gattringer T, et al · · 2021 · cited 92× · PMID 34746430 · DOI 10.1177/23969873211042192
Impact of physical activity in vascular cognitive impairment (AFIVASC): study protocol for a randomised controlled trial.
Verdelho A, Madureira S, Correia M, Ferro JM, et al · · 2019 · cited 4× · PMID 30744681 · DOI 10.1186/s13063-019-3174-1

Verify or expand the search:

Other trials of Physical Activity

Trials testing the same drug.

NCT07480811 — The Effect of the DASH Diet on Clinical and Metabolic Parameters in Children With MASLD · NA · not yet recruiting
NCT07125053 — COPD Resources, Education, and Activity Designed for You Study · NA · recruiting
NCT07099040 — Community-based Multi-domain Intervention to Detect and Delay Cognitive Decline in Community-dwelling Older Adults: A Pi · NA · not yet recruiting
NCT06948500 — Effectiveness of an IVR-based Therapeutic Exercise Program With Altered Visual Feedback in Fibromyalgia Patients · NA · recruiting
NCT06822387 — Health Without Barriers/Salud Sin Barreras- Northern Colorado · NA · recruiting

Other recruiting trials for Vascular Cognitive Impairment

Currently open trials in the same condition.

NCT07042633 — Mechanism of Gamma Oscillation Synchronization in the Prefrontal-hippocampal Circuit for Memory Dysfunction in Patients · recruiting
NCT05886114 — A Multi-domain Lifestyle Intervention Among Aged Community-residents in Zhejiang, China · NA · recruiting
NCT04916210 — Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03578614 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Instituto de Medicina Molecular João Lobo Antunes
Last refreshed: 1 April 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03578614.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing