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NCT03577249
Biological Effects of Citrate-buffered Solutions on Dialysis Efficiency and Systemic Inflammation
Phase 2, PHASE3 trial testing Dialysis Solutions in Renal Insufficiency, Chronic in 45 participants. Completed in 30 July 2015.
30 July 2015
Quick facts
| Lead sponsor | A.O.U. Città della Salute e della Scienza |
|---|---|
| Phase | Phase 2, PHASE3 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Design | sequential |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 45 |
| Start date | 30 October 2014 |
| Primary completion | 30 July 2015 |
| Estimated completion | 30 July 2015 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Dialysis Solutions — full drug profile →
Conditions studied
- Renal Insufficiency, Chronic — all drugs for Renal Insufficiency, Chronic →
- Inflammation — all drugs for Inflammation →
Sponsor
A.O.U. Città della Salute e della Scienza — full company profile →
Who can join
18 and older, any sex, with Renal Insufficiency, Chronic or Inflammation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In this study 45 patients undergoing weekly dialysis for chronic end stage renal disease will be enrolled. The patients will be treated with a standard dialysis solution, containing acetate buffer, for 3 months; subsequently the acetate will be substituted with citrate anion for the 3 following months and then, the last 3 months, the standard acetate-solution will be restarted. The aim of the study is to assess if acetate-to-citrate switch in the dialysis solution influences dialysis efficiency and patient inflammatory state.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Citrate anion improves chronic dialysis efficacy, reduces systemic inflammation and prevents Chemerin-mediated microvascular injury.
Dellepiane S, Medica D, Guarena C, Musso T, et al · · 2019 · cited 26× · PMID 31337804 · DOI 10.1038/s41598-019-47040-8
Verify or expand the search:
- PubMed search for NCT03577249
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other A.O.U. Città della Salute e della Scienza trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03577249 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by A.O.U. Città della Salute e della Scienza
- Last refreshed: 9 July 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03577249.
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