NCT03576989 is a NA clinical trial of EPA+DHA in Chronic Venous Leg Ulcers, sponsored by Ohio State University.

Who is sponsoring NCT03576989?

NCT03576989 is sponsored by Ohio State University.

What drugs are being tested in NCT03576989?

Interventions in NCT03576989: EPA+DHA, placebo.

What condition does NCT03576989 study?

NCT03576989 studies Chronic Venous Leg Ulcers.

Is NCT03576989 still recruiting?

NCT03576989 is currently completed. Last updated 24 December 2024.

Last reviewed 2024-12-24 · How we verify

NCT03576989

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Impact of Omega-3 Fatty Acid Oral Therapy on Healing of Chronic Venous Leg Ulcers in Older Adults

Completed NA Last updated 24 December 2024

What this trial tests

NA trial testing EPA+DHA in Chronic Venous Leg Ulcers in 296 participants. Completed in 18 December 2024.

Timeline

15 April 2019

Primary endpoint
18 December 2024

18 December 2024

Quick facts

Lead sponsor	Ohio State University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	296
Start date	15 April 2019
Primary completion	18 December 2024
Estimated completion	18 December 2024
Sites	1 location across United States

Drugs / interventions tested

EPA+DHA
placebo

Conditions studied

Chronic Venous Leg Ulcers — all drugs for Chronic Venous Leg Ulcers →

Sponsor

Ohio State University

Who can join

55 and older, any sex, with Chronic Venous Leg Ulcers. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to test the efficacy of an oral, nutrient intervention containing the bioactive components of fish oil to promote healing of chronic venous leg ulcers (CVLUs) by reducing the chronic inflammation at wound sites that prevents healing progression. If this systemic, nutrient intervention is found to alter the microenvironment of CVLUs, the science of wound healing and care of patients with CVLUs will be vastly improved.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

New Insights on the Effects of Dietary Omega-3 Fatty Acids on Impaired Skin Healing in Diabetes and Chronic Venous Leg Ulcers.
Serini S, Calviello G. · · 2021 · cited 9× · PMID 34681353 · DOI 10.3390/foods10102306
Impact of omega-3 fatty acid oral therapy on healing of chronic venous leg ulcers in older adults: Study protocol for a randomized controlled single-center trial.
McDaniel JC, Rausch J, Tan A. · · 2020 · cited 7× · PMID 31948466 · DOI 10.1186/s13063-019-3970-7
Study of Medical Ultrasound for Rhizarthrosis (SUR): study protocol for a randomized controlled single-center pilot-trial.
Bock M, Eisenschenk A, Lorenzen H, Lautenbach M. · · 2020 · cited 1× · PMID 32487163 · DOI 10.1186/s13063-020-04375-2
Expanding Use of Continuous Glucose Monitoring Beyond COVID in Critical Care: Study Protocol for a Hybrid Implementation Trial
Faulds E, Lee B, Rasul A, Jones L, et al · · 2024 · DOI 10.21203/rs.3.rs-4243392/v1

Verify or expand the search:

Other trials of EPA+DHA

Trials testing the same drug.

NCT03961763 — Effect of n-3 Fatty Acid Supplementation in Hyperlipidemic Patients Taking Statins · NA · completed

Other Ohio State University trials

Trials by the same sponsor.

NCT06542458 — Under-Represented Communities Diagnosed With SCD or MCI Through Tele-Cog · not yet recruiting
NCT07217548 — Solving Stigma Through POV Simulation: Enhancing Pharmacist Empathy-based Practices With Sickle Cell Disease Patients · NA · enrolling by invitation
NCT07215221 — Implementation of TBI-RECOVER in Substance Use Treatment · NA · not yet recruiting
NCT07278427 — Reducing Parental Substance Use and Enhancing Family Resilience Among Rural Families Through Ohio START · recruiting
NCT07490444 — Metric-Optimized Spectacle Prescriptions for Children With Down Syndrome · Phase 2 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03576989 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Ohio State University
Last refreshed: 24 December 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03576989.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing