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NCT03574493: RESET
Rectal Surgery Evaluation Trial (RESET)
trial testing TME with LAR in Rectal Cancer in 1,098 participants. Completed in 31 December 2024.
31 December 2022
Quick facts
| Lead sponsor | Institut du Cancer de Montpellier - Val d'Aurelle |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 1,098 |
| Start date | 16 October 2018 |
| Primary completion | 31 December 2022 |
| Estimated completion | 31 December 2024 |
| Sites | 1 location across France |
Drugs / interventions tested
- TME with LAR
Conditions studied
- Rectal Cancer — all drugs for Rectal Cancer →
Sponsor
Institut du Cancer de Montpellier - Val d'Aurelle — full company profile →
Who can join
18 and older, any sex, with Rectal Cancer. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Total mesorectal excision (TME) is the standard of care for rectal cancer, which can be combined with low anterior resection (LAR) in patients with mid-to-low rectal cancer. The narrow pelvic space and difficulties in obtaining adequate exposure make surgeries technically challenging. Four techniques are used to perform the surgery: open laparotomy, laparoscopy, robot-assisted surgery, and transanal surgery. Comparative data for these techniques is required to provide clinical data on the surgical management of rectal cancers by surgery.
Publications & conference data
6 peer-reviewed publications reference this trial (live from Europe PMC):
-
Robotic Surgery in Rectal Cancer: Potential, Challenges, and Opportunities.
Liu G, Zhang S, Zhang Y, Fu X, et al · · 2022 · cited 41× · PMID 35438444 · DOI 10.1007/s11864-022-00984-y -
MESOTIP: Phase II multicenter randomized trial evaluating the association of PIPAC and systemic chemotherapy vs. systemic chemotherapy alone as 1st-line treatment of malignant peritoneal mesothelioma.
Sgarbura O, Gourgou S, Tosi D, Bakrin N, et al · · 2019 · cited 22× · PMID 31417958 · DOI 10.1515/pp-2019-0010 -
A Prospective European Trial Comparing Laparotomy, Laparoscopy, Robotic-assisted, and Transanal Total Mesorectal Excision Procedures in High-risk Patients With Rectal Cancer: The RESET Trial.
Rouanet P, Guerrieri M, Lemercier P, Balik E, et al · · 2026 · cited 8× · PMID 39263755 · DOI 10.1097/sla.0000000000006534 -
3D pelvimetry and biometric measurements: a surgical perspective for colorectal resections.
Lorenzon L, Bini F, Landolfi F, Quinzi S, et al · · 2021 · cited 8× · PMID 33230658 · DOI 10.1007/s00384-020-03802-9 -
Intraperitoneal Chemotherapy for Peritoneal Metastases: Technical Innovations, Preclinical and Clinical Advances and Future Perspectives.
Christou N, Auger C, Battu S, Lalloué F, et al · · 2021 · cited 5× · PMID 33804167 · DOI 10.3390/biology10030225 -
Robotic-Assisted Surgery for Rectal Cancer: An Expedited Summary of the Clinical Evidence.
Ontario Health . · · 2024 · cited 1× · PMID 38645608
Verify or expand the search:
- PubMed search for NCT03574493
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03574493 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Institut du Cancer de Montpellier - Val d'Aurelle
- Last refreshed: 12 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03574493.
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