Who is sponsoring 5-AZA?

5-AZA is sponsored by The University of Texas Health Science Center, Houston.

What condition does 5-AZA study?

5-AZA studies Recurrent Ependymoma.

What drugs are being tested in 5-AZA?

Interventions: 5-Azacytidine (5-AZA) group 1, 5-Azacytidine (5-AZA) group 2, 5-Azacytidine (5-AZA) group 3.

Last reviewed 2025-04-08 · How we verify

Infusion of 5-Azacytidine (5-AZA) Into the Fourth Ventricle in Patients With Recurrent Posterior Fossa Ependymoma

NCT03572530 PHASE1 COMPLETED

This study seeks to determine the optimum dose frequency of 5-Azacytidin (5-AZA) infusions into the fourth ventricle of the brain. The study's primary objective is to establish the maximum tolerated dose for infusions of 5-Azacytidine into the fourth ventricle in patients with recurrent ependymoma. The study's secondary objective is to assess the antitumor activity of 5-Azacytidine infusions into the fourth ventricle based upon imaging studies and cytology.

Details

Lead sponsor	The University of Texas Health Science Center, Houston
Phase	PHASE1
Status	COMPLETED
Enrolment	3
Start date	Fri Feb 08 2019 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Tue Nov 24 2020 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

Recurrent Ependymoma

Interventions

5-Azacytidine (5-AZA) group 1
5-Azacytidine (5-AZA) group 2
5-Azacytidine (5-AZA) group 3

Countries

United States