Who is sponsoring NCT03572413?

NCT03572413 is sponsored by Radboud University Medical Center.

What drugs are being tested in NCT03572413?

Interventions in NCT03572413: Low pressure pneumoperitoneum, Rocuronium bromide.

What condition does NCT03572413 study?

NCT03572413 studies Pneumoperitoneum, Neuromuscular Blockade, Surgery, Immune Suppression.

Is NCT03572413 still recruiting?

NCT03572413 is currently completed. Last updated 3 November 2021.

Last reviewed 2021-11-03 · How we verify

NCT03572413: RECOVER-PLUS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Effect of Low Pressure Pneumoperitoneum During Laparoscopic Colorectal Surgery on Innate Immune Homeostasis.

Completed Phase 4 Last updated 3 November 2021

What this trial tests

Phase 4 trial testing Low pressure pneumoperitoneum in Pneumoperitoneum in 100 participants. Completed in 1 December 2020.

Timeline

24 October 2018

Primary endpoint
31 August 2020

1 December 2020

Quick facts

Lead sponsor	Radboud University Medical Center
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	100
Start date	24 October 2018
Primary completion	31 August 2020
Estimated completion	1 December 2020
Sites	1 location across Netherlands

Drugs / interventions tested

Low pressure pneumoperitoneum
Rocuronium bromide (Rocuronium Bromide) — full drug profile →

Conditions studied

Pneumoperitoneum — all drugs for Pneumoperitoneum →
Neuromuscular Blockade — all drugs for Neuromuscular Blockade →
Surgery — all drugs for Surgery →
Immune Suppression — all drugs for Immune Suppression →

Sponsor

Radboud University Medical Center

Who can join

18 and older, any sex, with Pneumoperitoneum or Neuromuscular Blockade. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Substudy of the RECOVER trial (a randomised controlled trial comparing the effect of low pressure pneumoperitoneum with deep neuromuscular block versus normal pressure pneumoperitoneum with moderate neuromuscular block during laparoscopic colorectal surgery on early quality of recovery) investigating innate immune homeostasis after laparoscopic colorectal surgery.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Quality of Recovery and Innate Immune Homeostasis in Patients Undergoing Low-pressure Versus Standard-pressure Pneumoperitoneum During Laparoscopic Colorectal Surgery (RECOVER): A Randomized Controlled Trial.
Albers KI, Polat F, Helder L, Panhuizen IF, et al · · 2022 · cited 32× · PMID 35822730 · DOI 10.1097/sla.0000000000005491
Postoperative Innate Immune Dysregulation, Proteomic, and Monocyte Epigenomic Changes After Colorectal Surgery: A Substudy of a Randomized Controlled Trial.
Albers-Warlé KI, Helder LS, Groh LA, Polat F, et al · · 2025 · cited 2× · PMID 39453841 · DOI 10.1213/ane.0000000000007297

Verify or expand the search:

Other trials of Low pressure pneumoperitoneum

Trials testing the same drug.

NCT04671121 — Pneumoperitoneum and Cerebral Oxygenation · NA · completed
NCT03608436 — The Effect of Low Pressure Pneumoperitoneum During Laparoscopic Colorectal Surgery on Early Quality of Recovery · Phase 4 · completed
NCT03020641 — Peritoneal Damage in Laparoscopic Surgery · NA · completed

Other recruiting trials for Pneumoperitoneum

Currently open trials in the same condition.

NCT06413264 — Ultrasonography Guided Pneumoperitoneum for Laparoscopic Surgery in Morbidly Obese Patients · NA · recruiting
NCT06685159 — Predictors of Postoperative Complications in Surgery With Pneumoperitoneum in the Trendelenburg Position · recruiting
NCT06447545 — Comparison Between Low Pressure Pneumoperitoneum with High Pressure Pneumoperitoneum in Post-operative Pain, Shoulder Ti · NA · recruiting

Other Radboud University Medical Center trials

Trials by the same sponsor.

NCT07485569 — Drug Repurposing in Thyroid Carcinoma: a Feasibility Trial · Phase 1 · not yet recruiting
NCT07514325 — MR-guided Adaptive Stereotactic Radiotherapy for Endometrial Cancer · NA · not yet recruiting
NCT07530263 — Deposition of Inhaled Liposomal Amphotericin B in Chronic Pulmonary Aspergillosis (CPA) · Phase 1 · not yet recruiting
NCT07532577 — Intranasal Insulin to Prevent Intensive Care Unit Delirium · Phase 2, PHASE3 · not yet recruiting
NCT07504172 — Real-world Effectiveness and Dosing Patterns of Tirzepatide in People With Obesity · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03572413 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Radboud University Medical Center
Last refreshed: 3 November 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03572413.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing