NCT03572205: FADSDIET2

Fatty Acid Desaturase Gene Locus Interactions With Diet (FADSDIET2)

Completed NA Last updated 18 April 2019

What this trial tests

NA trial testing LA in Fatty Acids in 140 participants. Completed in 19 December 2018.

Timeline

13 August 2018

Primary endpoint
19 December 2018

19 December 2018

Quick facts

Lead sponsor	University of Eastern Finland
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	other
Enrollment	140
Start date	13 August 2018
Primary completion	19 December 2018
Estimated completion	19 December 2018
Sites	1 location across Finland

Drugs / interventions tested

• LA
• ALA — full drug profile →

Conditions studied

• Fatty Acids — all drugs for Fatty Acids →
• Genetics — all drugs for Genetics →

Sponsor

University of Eastern Finland

Who can join

Adults 50 to 65, male only, with Fatty Acids or Genetics. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Interactions between genes and environment, are likely to be crucial in the development of the common diseases such as type 2 diabetes. Recently, the investigators have obtained data that genotypes of genes encoding for fatty acid desaturases 1 and 2 (FADS1 and FADS2) are the strongest genes in a genome-wide analysis regulating serum fatty acid profile.The aim of this study is to test if subjects with different genotypes of the FADS2 gene respond differently to a diet supplemented with linoleic acid or alpha-linolenic acid (substrates for FADS2). The study hypothesizes that subjects will be more sensitive to the dietary modifications according to their genotype leading to more robust differences in serum FA profile, tissue inflammation and serum lipids.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

1. Role of Oleic Acid in the Gut-Liver Axis: From Diet to the Regulation of Its Synthesis via Stearoyl-CoA Desaturase 1 (SCD1).
   Piccinin E, Cariello M, De Santis S, Ducheix S, et al · · 2019 · cited 109× · PMID 31554181 · DOI 10.3390/nu11102283
2. The FADS1 rs174550 Genotype Modifies the n-3 and n-6 PUFA and Lipid Mediator Responses to a High Alpha-Linolenic Acid and High Linoleic Acid Diets.
   Meuronen T, Lankinen MA, Kolmert J, de Mello VD, et al · · 2022 · cited 6× · PMID 36367234 · DOI 10.1002/mnfr.202200351
3. Modification in mitochondrial function is associated with the FADS1 variant and its interaction with alpha-linolenic acid-enriched diet-An exploratory study.
   Vaittinen M, Ilha M, Sehgal R, Lankinen MA, et al · · 2024 · cited 1× · PMID 39218219 · DOI 10.1016/j.jlr.2024.100638