18 and older, any sex, with Medication Non-adherence. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Retention RatePrimary· 3 months, 6 months
Percentage of participants retained in the study (n enrolled/n retained X 100)
3 months
Group
Value
95% CI
Mindfulness Training (MT)
31
6 months
Group
Value
95% CI
Mindfulness Training (MT)
29
Intervention AcceptabilityPrimary· 3 months
Self-reported intervention enjoyment scale (1 = did not enjoy to 5 = enjoyed very much). Scores range from 1 to 5; higher scores mean a better outcome. The metric for this study was the percentage of participants indicating high intervention enjoyment (a score of 5).
Medication Event Monitoring Systems (MEMS). Proportion of medication taken/medication prescribed x 100, averaged over 30 days. Range is 0-100%. Lower values indicate worse adherence.
6-min walk test (6MWT) distance. The 6 min walk test measures the distance a patient can walk on a level course in 6 min. It is a measure of functional capacity that correlates with peak oxygen uptake and is positively associated with survival in patients with cardiovascular disease. A higher value (in meters) indicates better functional capacity. The 6MWT distance in healthy adults has been reported to range from 400 to 700 meters.
baseline
Group
Value
95% CI
Mindfulness Training (MT)
350
± 93
3 months
Group
Value
95% CI
Mindfulness Training (MT)
378
± 97
6 months
Group
Value
95% CI
Mindfulness Training (MT)
374
± 95
The Flanker Inhibitory Control and Attention TestSecondary· baseline, 3 months, 6 months
Cognitive function was assessed using the NIH Toolbox Fluid Cognition Battery. Each neurocognitive test was independently completed by study participants (3-5 minutes each) using a study tablet after a baseline practice trial. For each cognitive measure we report age-adjusted scores, which are automatically generated by the NIH Toolbox software. For all measures, higher scores indicate better cognitive performance.
The Flanker Inhibitory Control and Attention Test is a measure of executive function, attention and inhibitory control. Participants are instructed to focus on a stimulus while inh
The Dimensional Change Card Sort Test is a measure of cognitive flexibility and attention. Two target pictures are presented that vary along two dimensions (e.g., shape and color). Participants are asked to match a series of bivalent test pictures (e.g., yellow balls and blue trucks) to the target pictures, first according to one dimension (e.g., color) and then, after a number of trials, according to the other dimension (e.g., shape). The relevant dimension for sorting is indicated by a cue word (e.g., "shape" or "color") that appears on the screen for all participants. Age-adjusted scores ar
Baseline
Group
Value
95% CI
Mindfulness Training (MT)
101
± 19.7
3 months
Group
Value
95% CI
Mindfulness Training (MT)
100.7
± 10.0
6 months
Group
Value
95% CI
Mindfulness Training (MT)
100.6
± 20.1
Oral Symbol Digit TestSecondary· baseline, 3 months, 6 months
The Oral Symbol digit test is a measure of working memory and processing speed. A key with nine abstract symbols is presented - each paired with a number between 1 and 9. Participants are asked to verbally indicate which numbers go with the symbols that are presented in a long string on the computer screen. The participant is given 120 seconds to call out as many numbers that go with the corresponding symbols as he/she can - in order, without skipping any. Age-adjusted scores were calculated automatically by the NIH Toolbox software. Higher scores indicate better function.
The Picture Sequence Memory Test is a measure of episodic memory. Sequences of pictured objects and activities are presented in a particular order. The participants are asked to reproduce the sequence of pictures that is shown on the screen. Participants respond by dragging pictures from the yellow box on the screen into the gray boxes on the screen.
Age-adjusted scores were calculated automatically by the NIH Toolbox software. Higher scores indicate better function.
Baseline
Group
Value
95% CI
Mindfulness Training (MT)
98.2
± 15.2
3 months
Group
Value
95% CI
Mindfulness Training (MT)
102.1
± 18.8
6 months
Group
Value
95% CI
Mindfulness Training (MT)
109.9
± 20.0
List Sorting Working Memory TestSecondary· baseline, 3 months, 6 months
The List Sorting Working Memory Test is a measure of working memory. Pictures of foods and animals are displayed with accompanying audio recording and written text (e.g., "elephant"), and the participant is asked to say the items back in size order from smallest to largest, first within a single dimension (either animals or foods) and then on two dimensions (foods, then animals). Age-adjusted scores were calculated automatically by the NIH Toolbox software. Higher scores indicate better function.
Pittsburgh Sleep Quality Index. Self-report measure of sleep quality and quantity. Higher scores indicate better sleep quality and quantity. The overall score range is 0-21.
baseline
Group
Value
95% CI
Mindfulness Training (MT)
7.2
± 3.9
3 months
Group
Value
95% CI
Mindfulness Training (MT)
6.9
± 3.9
6 months
Group
Value
95% CI
Mindfulness Training (MT)
7.6
± 4.6
Adverse events — posted to ClinicalTrials.gov
Time frame: 6 months.
Reporting threshold: 0%.
Adverse-event reports describe events observed during the trial — not all are caused by the drug.
This study investigated the feasibility and acceptability of a phone-delivered mindfulness intervention to improve medication adherence among outpatients with heart failure.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by The Miriam Hospital
Last refreshed: 14 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03571581.