NCT03568864 (TIDE) is a NA clinical trial of Low nucleotide meal in Healthy, sponsored by University of Exeter.

Who is sponsoring NCT03568864?

NCT03568864 is sponsored by University of Exeter.

What drugs are being tested in NCT03568864?

Interventions in NCT03568864: Low nucleotide meal, High nucleotide meal.

Is NCT03568864 still recruiting?

NCT03568864 is currently completed. Last updated 26 June 2018.

Last reviewed 2018-06-26 · How we verify

NCT03568864: TIDE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

High Nucleotide Meal Consumption in Uric Acid and Metabolic Health

Completed NA Last updated 26 June 2018

What this trial tests

NA trial testing Low nucleotide meal in Healthy in 10 participants. Completed in 14 March 2018.

Timeline

31 July 2017

Primary endpoint
14 March 2018

14 March 2018

Quick facts

Lead sponsor	University of Exeter
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	basic science
Enrollment	10
Start date	31 July 2017
Primary completion	14 March 2018
Estimated completion	14 March 2018
Sites	1 location across United Kingdom

Drugs / interventions tested

Low nucleotide meal
High nucleotide meal

Conditions studied

Healthy — all drugs for Healthy →

Sponsor

University of Exeter

Who can join

Adults 18 to 40, any sex, with Healthy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The production of protein rich animal products is associated with a large environmental burden, and with ethical considerations. Additionally, the over-consumption of meat might be associated with detrimental effects to health. Using mycoprotein, a food ingredient derived from the fermentation of a fungus, as a meat substitute could result in environmental benefits, and could have a role in managing obesity, diabetes and improving metabolic health. However, naturally produced mycoprotein has a high nucleotide content and little is known about the impact of nucleotides in uric acid levels and other health markers. The aim of this study is to investigate the effect of a meal based on nucleotide rich mycoprotein on uric acid concentrations and other markers of health.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Short-Communication: Ingestion of a Nucleotide-Rich Mixed Meal Increases Serum Uric Acid Concentrations but Does Not Affect Postprandial Blood Glucose or Serum Insulin Responses in Young Adults.
Coelho MOC, Monteyne AJ, Kamalanathan ID, Najdanovic-Visak V, et al · · 2020 · cited 8× · PMID 32316391 · DOI 10.3390/nu12041115

Verify or expand the search:

Other recruiting trials for Healthy

Currently open trials in the same condition.

NCT06707207 — Predicting Future Errors During Skill Performance · recruiting
NCT07169630 — PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI) · Phase 1 · recruiting
NCT07499414 — The Effects of the Bile Acid Supplement, 7-keto Lithocholic Acid, on Human Gut Microbiota and Risk Factors for Disease. · NA · recruiting
NCT07496697 — Effects of Electroacupuncture at NP82 and SP15 on Bowel Motility in Healthy Subjects · NA · recruiting
NCT06431932 — Pilot Trial of Fisetin in Healthy Volunteers and Older Patients With Multimorbidity · Phase 1, PHASE2 · recruiting

Other University of Exeter trials

Trials by the same sponsor.

NCT07457437 — Function and Lean Mass Preservation With Resistance Exercise During a GLP-1RA Treatment · NA · recruiting
NCT06478121 — Understanding Beta Cell Disorders Through the Study of Rare Genotypes (ENDURE) · recruiting
NCT06965699 — The Effect of a Plant-based, Protein-dense Sauce on Essential Amino Acid Concentrations and Gut Fullness in Older Adults · NA · recruiting
NCT06846294 — Obesity Prevention in Children and Young People Treated for Acute Lymphoblastic Leukaemia with ALLTogether · NA · not yet recruiting
NCT06852547 — The Effect of Ingesting a Novel Algae Protein Source on Rested and Exercised Muscle Protein Synthesis Rates in Older Adu · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03568864 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Exeter
Last refreshed: 26 June 2018

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03568864.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing