NCT03565575

Manicaland PrEP Uptake Through Interactive Counselling Trial

Completed NA Last updated 28 September 2023

What this trial tests

NA trial testing Interactive tablet-based quiz in Improving Perceptions of HIV Risk in 1,055 participants. Completed in 30 January 2021.

Timeline

7 July 2018

Primary endpoint
30 January 2021

30 January 2021

Quick facts

Lead sponsor	Simon Gregson
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	1,055
Start date	7 July 2018
Primary completion	30 January 2021
Estimated completion	30 January 2021
Sites	8 locations across Zimbabwe

Drugs / interventions tested

• Interactive tablet-based quiz

Conditions studied

• Improving Perceptions of HIV Risk — all drugs for Improving Perceptions of HIV Risk →
• Improving Uptake of Pre-exposure Prophylaxis for HIV — all drugs for Improving Uptake of Pre-exposure Prophylaxis for HIV →

Sponsor

Simon Gregson

Who can join

Adults 18 to 24, female only, with Improving Perceptions of HIV Risk or Improving Uptake of Pre-exposure Prophylaxis for HIV. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Primary Objective:

The purpose of this trial is to evaluate the impact of an interactive tablet based counselling session correcting risk perception and addressing ambiguity around availability, usability and effectiveness of PrEP on PrEP uptake within 6 months in adolescent girls and young women (AGYW) aged 18-24 years.

Hypothesis:

Correcting misperceptions of risks of HIV infection and off-setting ambiguity effects about the availability, usability and efficacy of PrEP, through localized, interactive, tablet-based counselling, will increase uptake of PrEP in HIV-negative AGYW.

Study outcomes:

The primary outcomes for the study will be risk perception measured in a follow-up survey at 6 months and proportion of women taking up PrEP within 6 months measured with biomarkers of plasma antiretroviral (ARV) drug presence.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

1. Cost-effectiveness of easy-access, risk-informed oral pre-exposure prophylaxis in HIV epidemics in sub-Saharan Africa: a modelling study.
   Phillips AN, Bershteyn A, Revill P, Bansi-Matharu L, et al · · 2022 · cited 42× · PMID 35489378 · DOI 10.1016/s2352-3018(22)00029-7
2. Application of the HIV prevention cascade to identify, develop and evaluate interventions to improve use of prevention methods: examples from a study in east Zimbabwe.
   Moorhouse L, Schaefer R, Thomas R, Nyamukapa C, et al · · 2019 · cited 41× · PMID 31328375 · DOI 10.1002/jia2.25309
3. Improving risk perception and uptake of pre-exposure prophylaxis (PrEP) through interactive feedback-based counselling with and without community engagement in young women in Manicaland, East Zimbabwe: study protocol for a pilot randomized trial.
   Thomas R, Skovdal M, Galizzi MM, Schaefer R, et al · · 2019 · cited 19× · PMID 31791405 · DOI 10.1186/s13063-019-3791-8
4. Mobile Health Intervention Tools Promoting HIV Pre-Exposure Prophylaxis Among Adolescent Girls and Young Women in Sub-Saharan Africa: Scoping Review.
   Fischer AE, Hanif H, Stocks JB, Rochelle AE, et al · · 2025 · cited 5× · PMID 40540732 · DOI 10.2196/60819
5. Gender Norms and Structural Barriers to Use of HIV Prevention in Unmarried and Married Young Women in Manicaland, Zimbabwe: An HIV Prevention Cascade Analysis.
   Gregson S, Moorhouse L, Maswera R, Dadirai T, et al · · 2024 · PMID 40895466 · DOI 10.12688/gatesopenres.15127.2