NCT03565510

The Impact of a High-protein Diet on Energy Metabolism in Healthy Men

Completed NA Last updated 23 January 2020

What this trial tests

NA trial testing High-Protein Diet in Dietary Modification in 27 participants. Completed in 31 October 2019.

Timeline

1 August 2018

Primary endpoint
31 October 2019

31 October 2019

Quick facts

Lead sponsor	University of Alberta
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	basic science
Enrollment	27
Start date	1 August 2018
Primary completion	31 October 2019
Estimated completion	31 October 2019
Sites	1 location across Canada

Drugs / interventions tested

• High-Protein Diet

Conditions studied

• Dietary Modification — all drugs for Dietary Modification →

Sponsor

University of Alberta

Who can join

Adults 18 to 35, male only, with Dietary Modification. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of this study is to investigate the impact of a high-protein diet (achieved with the use of a nutritional supplement, Almased®) versus a diet of a typical North American macronutrient distribution on energy metabolism, metabolic blood markers and appetite sensations.

This study will be a randomized, controlled, cross-over trial of an acute nutritional intervention. A total of 20 participants will be randomly assigned (1:1) to one of the following groups:

* Control group (CON).
* High protein diet group (HP).

The diets given to participants in both groups will be eucaloric.

While receiving the diets in the whole body calorimetry unit for 32 hours, participants' overall changes in energy metabolism, metabolic blood markers, and appetite sensations will be assessed.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

1. A high-protein total diet replacement increases energy expenditure and leads to negative fat balance in healthy, normal-weight adults.
   Oliveira CLP, Boulé NG, Sharma AM, Elliott SA, et al · · 2021 · cited 17× · PMID 33247306 · DOI 10.1093/ajcn/nqaa283
2. Consumption of a High-Protein Meal Replacement Leads to Higher Fat Oxidation, Suppression of Hunger, and Improved Metabolic Profile After an Exercise Session.
   Oliveira CLP, Boulé NG, Berg A, Sharma AM, et al · · 2021 · cited 14× · PMID 33466462 · DOI 10.3390/nu13010155
3. A high-protein total diet replacement alters the regulation of food intake and energy homeostasis in healthy, normal-weight adults.
   Oliveira CLP, Boulé NG, Elliott SA, Sharma AM, et al · · 2022 · cited 8× · PMID 34928408 · DOI 10.1007/s00394-021-02747-1
4. Examining the effects of a high-protein total diet replacement on energy metabolism, metabolic blood markers, and appetite sensations in healthy adults: protocol for two complementary, randomized, controlled, crossover trials.
   Oliveira CLP, Boulé NG, Sharma AM, Elliott S, et al · · 2019 · cited 7× · PMID 31881910 · DOI 10.1186/s13063-019-3950-y