Effect of Steroid Administration on Maternal Blood Levels of hLPCAT1 mRNA

NCT03562182 UNKNOWN

Neonatal respiratory distress syndrome affects babies who are born preterm and requires them to be placed on a ventilator in the Intensive Care Unit. Over 15 million babies were born premature and these numbers have been increasing. It is caused by lungs which are still too immature to produce adequate amounts of surfactant. This surfactant reduces the alveolar surface tension and maintains the alveoli from collapsing. Collapsed alveoli prevent gas exchange and greatly increase work of breathing. Surfactant is a biochemical complex made up mostly of phospholipids such as phosphatidylcholine and phosphatidylglycerol and these, in turn, appear to be synthesized by lysophosphatidylcholine acyltransferase 1 (LPCAT 1). The investigators have previously established that hLPCAT1 mRNA in maternal serum correlates with lamellar body count, a well established clinical marker of fetal lung maturity.

Details

Lead sponsor	Wayne State University
Status	UNKNOWN
Enrolment	80
Start date	2018-06-18
Completion	2022-05

Conditions

• Fetal Lung Maturity
• Respiratory Distress Syndrome in Premature Infant

Interventions

• blood draw

Primary outcomes

• Change in LPCAT1 mRNA levels in maternal plasma after antenatal steroid administration — The time points will be a baseline before steroids, 24h after the first dose, 24h after the second dose, a week after steroids and two weeks after steroids.
  The investigators will measure the level of LPCAT1 mRNA in maternal plasma before and after the administration of antenatal steroids.

Countries

United States