Last reviewed · How we verify
NCT03560310: TACSI
Ticagrelor and ASA vs. ASA Only After Isolated Coronary Artery Bypass Grafting in Patients With Acute Coronary Syndrome
Phase 4 trial testing Ticagrelor 90mg twice daily and ASA 75-100 mg daily in Acute Coronary Syndrome in 2,201 participants. Participants enrolled and being followed up; not accepting new ones.
13 March 2025
Quick facts
| Lead sponsor | Vastra Gotaland Region |
|---|---|
| Phase | Phase 4 |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 2,201 |
| Start date | 29 June 2018 |
| Primary completion | 13 March 2025 |
| Estimated completion | 15 February 2035 |
| Sites | 22 locations across Denmark, Finland, Sweden, Norway, Iceland |
Drugs / interventions tested
- Ticagrelor 90mg twice daily and ASA 75-100 mg daily — full drug profile →
- ASA 75-160 mg daily — full drug profile →
Conditions studied
- Acute Coronary Syndrome — all drugs for Acute Coronary Syndrome →
Sponsor
Vastra Gotaland Region — full company profile →
Who can join
18 and older, any sex, with Acute Coronary Syndrome. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The study is a Randomised Registry-based Clinical Trial (RRCT) to assess whether dual antiplatelet therapy with ticagrelor and ASA compared to ASA alone improves outcome after isolated CABG in patients with acute coronary syndrome.
Publications & conference data
7 peer-reviewed publications reference this trial (live from Europe PMC):
-
De-escalation of antiplatelet therapy in acute coronary syndromes: Why, how and when?
Galli M, Angiolillo DJ. · · 2022 · cited 27× · PMID 36093167 · DOI 10.3389/fcvm.2022.975969 -
Ticagrelor and Aspirin or Aspirin Alone after Coronary Surgery for Acute Coronary Syndrome.
Jeppsson A, James S, Moller CH, Malm CJ, et al · · 2025 · cited 11× · PMID 40888737 · DOI 10.1056/nejmoa2508026 -
Dual or single antiplatelet therapy after coronary surgery for acute coronary syndrome (TACSI trial): Rationale and design of an investigator-initiated, prospective, multinational, registry-based randomized clinical trial.
Malm CJ, Alfredsson J, Erlinge D, Gudbjartsson T, et al · · 2023 · cited 8× · PMID 36681173 · DOI 10.1016/j.ahj.2023.01.011 -
Antithrombotic strategies for preventing graft failure in coronary artery bypass graft.
Mauro MS, Finocchiaro S, Calderone D, Rochira C, et al · · 2024 · cited 6× · PMID 38491265 · DOI 10.1007/s11239-023-02940-5 -
Antiplatelet therapy around CABG: the latest evidence.
Sandner S, Redfors B, Gaudino M. · · 2023 · cited 5× · PMID 37751394 · DOI 10.1097/hco.0000000000001078 -
Clinical Trials With Pragmatic Elements: A Review of Use Cases and Real-World Data Utilization.
Su L, Chen L, Betigeri S, Dreyer N, et al · · 2025 · cited 3× · PMID 40827586 · DOI 10.1002/cpt.70033 -
Short- and long-term outcomes of ST-segment elevation myocardial infarction treated with CABG: a population-based cohort study.
Saura E, Anttila V, Gunn J, Kytö V. · · 2025 · PMID 40374230 · DOI 10.1136/bmjopen-2024-089451
Verify or expand the search:
- PubMed search for NCT03560310
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Acute Coronary Syndrome
Currently open trials in the same condition.
- NCT06535568 — Single vs. Dual Antiplatelet Therapy in Elderly or HBR Patients Undergoing Percutaneous Intervention With DCB (PICCOLETO · NA · recruiting
- NCT07230847 — A Study Evaluating the Vascular Healing and Neointimal Transformation at 1 Month After Implantation of BioFreedom™ Drug- · NA · recruiting
- NCT07032389 — A Polypill for Acute Coronary Syndrome · Phase 2 · recruiting
- NCT07102628 — Evaluation of Efficacy and Safety of Early in Hospital Initiation of Inclisiran Treatment in Patients With Acute Coronar · Phase 3 · recruiting
- NCT06416813 — Preventive Intervention Value of DCB in Vulnerable Coronary Atherosclerotic Plaques · NA · active not recruiting
Other Vastra Gotaland Region trials
Trials by the same sponsor.
- NCT07430865 — The RECOVER Study - Postpartum Recovery of Pelvic Floor Structures and the Impact of Early Rehabilitation · NA · recruiting
- NCT07472335 — Home-based Acute Care for Older Persons Initiated by the Emergency Medical and Ambulance Services - a Retrospective Obse · not yet recruiting
- NCT07246577 — The VGR GCA Cohort: Ultrasound, Biopsy and Biomarkers - Novel Methods for Diagnosis, Monitoring and Prognosis in Giant C · recruiting
- NCT07449338 — Prospective Cohort Study of Response and Tolerability of Accelerated Intermittent Theta-burst Stimulation (1W-AiTBS) · not yet recruiting
- NCT07334340 — Modified vs Standard CDED: Evaluation of a Nordic Adaptation of Nutritional Therapy in Paediatric Crohn's Disease · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03560310 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Vastra Gotaland Region
- Last refreshed: 2 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03560310.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing