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NCT03557645: VHI-HD
Ventilator Hyperinflation and Hemodynamics
NA trial testing Baseline Mechanical Ventilation in Respiratory Failure in 17 participants. Completed in 30 September 2018.
20 September 2018
Quick facts
| Lead sponsor | Centro Universitário Augusto Motta |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 17 |
| Start date | 5 November 2017 |
| Primary completion | 20 September 2018 |
| Estimated completion | 30 September 2018 |
| Sites | 1 location across Brazil |
Drugs / interventions tested
- Baseline Mechanical Ventilation
- VHI With Inspiratory Pause
- VHI Without Inspiratory Pause
Conditions studied
- Respiratory Failure — all drugs for Respiratory Failure →
- Respiratory Disorders — all drugs for Respiratory Disorders →
Sponsor
Centro Universitário Augusto Motta
Who can join
Adults 18 to 90, any sex, with Respiratory Failure or Respiratory Disorders. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Ventilator hyperinflation (VHI) has been shown to be effective in improving respiratory mechanics, secretion removal, and gas exchange in mechanically ventilated patients; however, the literature is scarce concerning its safety and adverse effects. Thus, the aim of this study is to compare the hemodynamic repercussions of VHI in volume-controlled mode. In a randomized, controlled and crossover design, 24 mechanically ventilated patients will undergo 2 modes of ventilator hyperinflation (with and without an inspiratory pause) and a control intervention. Cardiac output, cardiac index, mean arterial pressure, pulmonary vascular resistance, systolic volume and other hemodynamic variables will be recorded during the interventions.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03557645
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Centro Universitário Augusto Motta trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03557645 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Centro Universitário Augusto Motta
- Last refreshed: 14 August 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03557645.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing