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NCT03551951
Tumor Cell and DNA Detection in the Blood, Urine, and Bone Marrow
trial testing Test for circulating tumor cells, DNA alterations in Non Small Cell Lung Cancer in 320 participants. Currently enrolling.
30 December 2027
Quick facts
| Lead sponsor | University of Missouri-Columbia |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 320 |
| Start date | 1 July 2016 |
| Primary completion | 30 December 2027 |
| Estimated completion | 30 December 2027 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Test for circulating tumor cells, DNA alterations
Conditions studied
- Non Small Cell Lung Cancer — all drugs for Non Small Cell Lung Cancer →
- Esophageal Cancer — all drugs for Esophageal Cancer →
- Gastric Cancer — all drugs for Gastric Cancer →
- Pancreatic Cancer — all drugs for Pancreatic Cancer →
Sponsor
University of Missouri-Columbia
Who can join
18 and older, any sex, with Non Small Cell Lung Cancer or Esophageal Cancer. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Patients with resectable solid primary cancers and even limited number of metastases are potentially curable. However, most patients develop recurrences despite surgery. Also, early detection of lung cancer with low dose CT screening may cure patients at an early stage. Circulating and disseminated tumor cell (CTC/DTC) and circulating cell-free (cf) DNA isolation from the blood, urine and bone marrow will increase understanding of cancer spread and advance knowledge to develop individualized therapies and improve screening.
Publications & conference data
6 peer-reviewed publications reference this trial (live from Europe PMC):
-
PD-L1 Expression with Epithelial Mesenchymal Transition of Circulating Tumor Cells Is Associated with Poor Survival in Curatively Resected Non-Small Cell Lung Cancer.
Manjunath Y, Upparahalli SV, Avella DM, Deroche CB, et al · · 2019 · cited 67× · PMID 31212653 · DOI 10.3390/cancers11060806 -
Circulating Tumor Cells in Pancreatic Cancer: Current Perspectives.
Martini V, Timme-Bronsert S, Fichtner-Feigl S, Hoeppner J, et al · · 2019 · cited 61× · PMID 31717773 · DOI 10.3390/cancers11111659 -
Current Applications of Liquid Biopsy in Gastrointestinal Cancer Disease-From Early Cancer Detection to Individualized Cancer Treatment.
David P, Mittelstädt A, Kouhestani D, Anthuber A, et al · · 2023 · cited 10× · PMID 37046585 · DOI 10.3390/cancers15071924 -
Circulating Tumor-Macrophage Fusion Cells and Circulating Tumor Cells Complement Non-Small-Cell Lung Cancer Screening in Patients With Suspicious Lung-RADS 4 Nodules.
Manjunath Y, Suvilesh KN, Mitchem JB, Avella Patino DM, et al · · 2022 · cited 10× · PMID 35417204 · DOI 10.1200/po.21.00378 -
Molecular subtypes of colorectal cancer in the era of precision oncotherapy: Current inspirations and future challenges.
Dang Q, Zuo L, Hu X, Zhou Z, et al · · 2024 · cited 9× · PMID 39054866 · DOI 10.1002/cam4.70041 -
Circulating tumor cells in pancreatic cancer: more than liquid biopsy.
Li Z, Qin C, Zhao B, Li T, et al · · 2024 · cited 3× · PMID 39421679 · DOI 10.1177/17588359241284935
Verify or expand the search:
- PubMed search for NCT03551951
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03551951 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Missouri-Columbia
- Last refreshed: 8 October 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03551951.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing