Last reviewed · How we verify
NCT03546049: PUMa
Ultrasound-guided Percutaneous Biliary Drainage Versus Endoscopic Ultrasound-guided Biliary Drainage
NA trial testing US-guided percutaneous biliary drainage in Bile Duct Obstruction, Extrahepatic in 216 participants. Status unknown.
1 September 2024
Quick facts
| Lead sponsor | Theresienkrankenhaus und St. Hedwig-Klinik GmbH |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 216 |
| Start date | 1 December 2018 |
| Primary completion | 1 September 2024 |
| Estimated completion | 1 December 2024 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- US-guided percutaneous biliary drainage
- EUS-guided biliary drainage
Conditions studied
- Bile Duct Obstruction, Extrahepatic — all drugs for Bile Duct Obstruction, Extrahepatic →
Sponsor
Theresienkrankenhaus und St. Hedwig-Klinik GmbH — full company profile →
Who can join
18 and older, any sex, with Bile Duct Obstruction, Extrahepatic. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Prospective multi-site study of ultrasound-guided percutaneous biliary drainage and endoscopic ultrasound-guided biliary drainage with implantation of a self-expanding metal stent in patients with malignant, distal bile duct obstruction (PUMa-study)
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Percutaneous transhepatic or endoscopic ultrasound-guided biliary drainage in malignant distal bile duct obstruction using a self-expanding metal stent: Study protocol for a prospective European multicenter trial (PUMa trial).
Schmitz D, Valiente CT, Dollhopf M, Perez-Miranda M, et al · · 2022 · cited 9× · PMID 36302047 · DOI 10.1371/journal.pone.0275029 -
Endoscopic ultrasound-guided biliary drainage <i>vs</i> percutaneous transhepatic biliary drainage for malignant biliary obstruction after endoscopic retrograde cholangiopancreatography failure.
Zhao H, Zhang XW, Song P, Li X. · · 2024 · cited 1× · PMID 39649198 · DOI 10.4240/wjgs.v16.i11.3614
Verify or expand the search:
- PubMed search for NCT03546049
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03546049 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Theresienkrankenhaus und St. Hedwig-Klinik GmbH
- Last refreshed: 29 August 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03546049.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing