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NCT03543228: Prefect
MyoStrain CMR for the Detection of Cardiotoxicity
trial testing MyoStrain in Cardiotoxicity in 63 participants. Completed in 31 January 2020.
31 January 2020
Quick facts
| Lead sponsor | Myocardial Solutions |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 63 |
| Start date | 1 August 2017 |
| Primary completion | 31 January 2020 |
| Estimated completion | 31 January 2020 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- MyoStrain
Conditions studied
- Cardiotoxicity — all drugs for Cardiotoxicity →
- Heart Failure — all drugs for Heart Failure →
- Chemotherapeutic Toxicity — all drugs for Chemotherapeutic Toxicity →
Sponsor
Myocardial Solutions
Who can join
Adults 18 to 80, any sex, with Cardiotoxicity or Heart Failure. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The Prefect Pilot Study evaluates the use of the EC approved MyoStrain SENC CMR Imaging System to detect cardiotoxicity from drugs used to treat cancer (e.g. Breast Cancer and Lymphomas).
Publications & conference data
5 peer-reviewed publications reference this trial (live from Europe PMC):
-
Multiparametric Early Detection and Prediction of Cardiotoxicity Using Myocardial Strain, T1 and T2 Mapping, and Biochemical Markers: A Longitudinal Cardiac Resonance Imaging Study During 2 Years of Follow-Up.
Giusca S, Korosoglou G, Montenbruck M, Geršak B, et al · · 2021 · cited 55× · PMID 34126756 · DOI 10.1161/circimaging.121.012459 -
Abstracts of the Heart Failure 2019 and the World Congress on Acute Heart Failure, 25-28 May 2019, Megaron Athens International Conference Centre, Greece.
· 2019 · cited 5× · PMID 32745277 · DOI 10.1002/ejhf.1488 -
Relationship Between Quality of Life Indicators and Cardiac Status Indicators in Chemotherapy Patients.
Geršak BM, Kukec A, Steen H, Montenbruck M, et al · · 2021 · cited 3× · PMID 34917188 · DOI 10.2478/sjph-2021-0028 -
Cardiotoxicity Monitoring in Patients With Cancer: Focus on Safety and Clinical Relevance.
Suero-Abreu GA, Ganatra S, Neilan TG. · · 2021 · cited 2× · PMID 33793304 · DOI 10.1200/op.21.00075 -
Myocardial Strain Measurements Obtained with Fast-Strain-Encoded Cardiac Magnetic Resonance for the Risk Prediction and Early Detection of Chemotherapy-Related Cardiotoxicity Compared to Left Ventricular Ejection Fraction.
Lenihan D, Whayne J, Osman F, Rivero R, et al · · 2025 · PMID 40804912 · DOI 10.3390/diagnostics15151948
Verify or expand the search:
- PubMed search for NCT03543228
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of MyoStrain
Trials testing the same drug.
- NCT03543241 — MyoStrain CMR Testing of Ischemia With Low Levels of Stress · completed
Other recruiting trials for Cardiotoxicity
Currently open trials in the same condition.
- NCT07442578 — Impact of Exercise Intensity on Cardiac Health in Young Adult Survivors of Childhood Cancer: The PULSE Trial · NA · active not recruiting
- NCT06778122 — In-Bedroom Renewed Air as Anti-inflammatory Adjuvant Therapy in Cancer Survivors · NA · recruiting
- NCT07382141 — Early Identification of Cardivascular Damage Induced by Chemotherapy and Antineoplastic Treatments in Pediatric Age · NA · recruiting
- NCT06595147 — Breast cancEr, FITness and ExeRcise for Heart Health: The BE-FITTER Study · NA · recruiting
- NCT06270667 — Effects of Exercise Training in Survivors of Lymphoma · NA · recruiting
Other Myocardial Solutions trials
Trials by the same sponsor.
- NCT03543241 — MyoStrain CMR Testing of Ischemia With Low Levels of Stress · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03543228 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Myocardial Solutions
- Last refreshed: 25 June 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03543228.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing