NCT03542708 (PRP4POI) is a NA clinical trial of A-PRP in Primary Ovarian Insufficiency, sponsored by Center for Human Reproduction.

Who is sponsoring NCT03542708?

NCT03542708 is sponsored by Center for Human Reproduction.

What drugs are being tested in NCT03542708?

Interventions in NCT03542708: A-PRP.

What condition does NCT03542708 study?

NCT03542708 studies Primary Ovarian Insufficiency, Premature Menopause.

Is NCT03542708 still recruiting?

NCT03542708 is currently completed. Last updated 10 July 2024.

Last reviewed 2024-07-10 · How we verify

NCT03542708: PRP4POI

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Injections of Autologous PRP in Women With Primary Ovarian Insufficiency

Completed NA Last updated 10 July 2024

What this trial tests

NA trial testing A-PRP in Primary Ovarian Insufficiency in 34 participants. Completed in 1 April 2024.

Timeline

25 July 2018

Primary endpoint
1 April 2024

1 April 2024

Quick facts

Lead sponsor	Center for Human Reproduction
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	34
Start date	25 July 2018
Primary completion	1 April 2024
Estimated completion	1 April 2024
Sites	1 location across United States

Drugs / interventions tested

A-PRP

Conditions studied

Primary Ovarian Insufficiency — all drugs for Primary Ovarian Insufficiency →
Premature Menopause — all drugs for Premature Menopause →

Sponsor

Center for Human Reproduction — full company profile →

Who can join

Adults 21 to 40, female only, with Primary Ovarian Insufficiency or Premature Menopause. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Premature ovarian failure is a loss of normal function before age 40, leading to infertility and hypoestrogenism. This study will involve only adult women with a diagnosis of POI. Participants will receive injections of autologous PRP in one randomly selected ovary.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Preliminary report of intraovarian injections of autologous platelet-rich plasma (PRP) in extremely poor prognosis patients with only oocyte donation as alternative: a prospective cohort study.
Barad DH, Albertini DF, Molinari E, Gleicher N. · · 2022 · cited 22× · PMID 35795849 · DOI 10.1093/hropen/hoac027
Therapeutic roles of platelet-rich plasma to restore female reproductive and endocrine dysfunction.
Wang X, Li J, Lu W, Gao F, et al · · 2024 · cited 8× · PMID 38654928 · DOI 10.3389/fendo.2024.1374382
Platelet-Rich Plasma (PRP) in Reproductive Medicine: A Critical Review of PRP Therapy in Low-Reserve and Premature Ovarian Insufficiency.
Moustakli E, Potiris A, Zikopoulos A, Zachariou A, et al · · 2025 · cited 2× · PMID 40427083 · DOI 10.3390/biomedicines13051257
Research trends on platelet-rich plasma in improving ovarian dysfunction: A bibliometric and visualization analysis.
Liu F, Li J, Li J, Lan M, et al · · 2025 · PMID 41079455 · DOI 10.1016/j.reth.2025.09.010

Verify or expand the search:

Other trials of A-PRP

Trials testing the same drug.

NCT04275700 — Study of PRP in Women With Evidence of Diminished Ovarian Reserve · NA · completed

Other recruiting trials for Primary Ovarian Insufficiency

Currently open trials in the same condition.

NCT07357701 — Identifying Genome Variants in Non-Obstructive Azoospermia (NOA) or Primary Ovarian Insufficiency (POI) · recruiting
NCT06357442 — Assessment of Endometrial Thickness Among Adolescent and Young Adult Patients on Estrogen Replacement Therapy Using Dail · recruiting
NCT06167135 — Polycystic Ovary Syndrome, Mitochondrial Dysfunction, Obesity, Insulin Resistance Infertility (POMODORI) Cohort · recruiting
NCT05327283 — Investigation of Copy Number Variations and Genetic Variants in POI · recruiting

Other Center for Human Reproduction trials

Trials by the same sponsor.

NCT04278313 — Ovarian Function Following Intraovarian Injection of PRP · NA · active not recruiting
NCT04275700 — Study of PRP in Women With Evidence of Diminished Ovarian Reserve · NA · completed
NCT02947217 — Effect of Influenza Vaccination on IVF Outcomes - IVF · Phase 4 · unknown
NCT02946177 — Effect of Influenza Vaccination on Donor Egg Recipient Outcomes · Phase 4 · unknown
NCT01662466 — Effect of Testosterone Treatment on Embryo Quality · Phase 1, PHASE2 · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03542708 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Center for Human Reproduction
Last refreshed: 10 July 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03542708.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing