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NCT03542630
Evaluation of Matrix Metalloproteinase 8 Salivary Test for Diagnosis of Periodontitis
trial testing salivary MMP8 test in Periodontitis in 100 participants. Completed in 1 May 2021.
1 May 2021
Quick facts
| Lead sponsor | University of Zagreb |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 100 |
| Start date | 1 January 2018 |
| Primary completion | 1 May 2021 |
| Estimated completion | 1 May 2021 |
| Sites | 1 location across Croatia |
Drugs / interventions tested
- salivary MMP8 test
- periodontal examination
- blood tests — full drug profile →
Conditions studied
- Periodontitis — all drugs for Periodontitis →
- Gingivitis — all drugs for Gingivitis →
- Infertility — all drugs for Infertility →
Sponsor
University of Zagreb
Who can join
Adults 25 to 42, female only, with Periodontitis or Gingivitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Despite the great progress in understanding the causes of infertility, the reason for the failure of pregnancy has not been discovered among 25% of infertile couples. Some studies have shown the negative impact of periodontal disease on the reproductive potential of women. It is known that there is an elevated level of matrix metalloproteinase 8 (MMP8) in the gingival fluid of patients with periodontitis. It is possible to establish a fast diagnosis of periodontitis by using a non-invasive assay based on monoclonal antibodies to two epitopes of MMP-8. The goal of the research is to use the above described assay in order to compare the level of MMP8 in the gingival fluid of infertile patients with the control group of fertile women, depending on the existence of periodontal disease. It is expected to find significantly higher values of MMP8 in infertile patients in relation to the fertile patient with/without periodontitis. The prompt treatment of periodontitis in preconception care of this group of women could have a significant impact on the improvement of fertility and ability to achieve pregnancy.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Diagnostic Accuracy of Salivary aMMP-8 Test in Infertile Women and Blood Finding Analysis.
Šumilin L, Musić L, Puhar I, Sabol I, et al · · 2022 · cited 4× · PMID 35821727 · DOI 10.15644/asc56/2/1
Verify or expand the search:
- PubMed search for NCT03542630
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Other University of Zagreb trials
Trials by the same sponsor.
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- NCT07460557 — Morphological Characteristics of the Maxillomandibular Region in a 3D Representation and the Refractive Status of the Ey · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03542630 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Zagreb
- Last refreshed: 29 September 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03542630.
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