NCT03542253

Combined Diagnosis of CT and Exosome in Early Lung Cancer

Status unknown Last updated 31 May 2018

What this trial tests

trial testing Surgery in Early Lung Cancer in 80 participants. Status unknown.

Timeline

20 May 2018

Primary endpoint
30 May 2019

30 June 2019

Quick facts

Lead sponsor	Second Affiliated Hospital of Soochow University
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	80
Start date	20 May 2018
Primary completion	30 May 2019
Estimated completion	30 June 2019

Drugs / interventions tested

• Surgery

Conditions studied

• Early Lung Cancer — all drugs for Early Lung Cancer →

Sponsor

Second Affiliated Hospital of Soochow University

Who can join

Eligibility, any sex, with Early Lung Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This experiment has now collected 50 cases, all through CT chest scans and blood exosome detection. Twenty-two patients underwent surgical treatment and 14 tissue specimens were examined for cancer and paracancerous tissue exosomesWe found that exosomal micor-A was highly expressed in early stage lung cancer tissues and was significantly higher than paracancerous tissues. The micor-A in the adjacent tissues was significantly higher than that in peripheral blood exosomes

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Emerging role of exosomes in cancer progression and tumor microenvironment remodeling.
   Paskeh MDA, Entezari M, Mirzaei S, Zabolian A, et al · · 2022 · cited 398× · PMID 35765040 · DOI 10.1186/s13045-022-01305-4
2. Exosome-based immunotherapy: a promising approach for cancer treatment.
   Xu Z, Zeng S, Gong Z, Yan Y. · · 2020 · cited 373× · PMID 33183286 · DOI 10.1186/s12943-020-01278-3
3. Cancer-Derived Exosomes: Their Role in Cancer Biology and Biomarker Development.
   Kok VC, Yu CC. · · 2020 · cited 318× · PMID 33116515 · DOI 10.2147/ijn.s272378
4. Progress on pivotal role and application of exosome in lung cancer carcinogenesis, diagnosis, therapy and prognosis.
   Li MY, Liu LZ, Dong M. · · 2021 · cited 185× · PMID 33504342 · DOI 10.1186/s12943-021-01312-y
5. Potential Use of Exosomes as Diagnostic Biomarkers and in Targeted Drug Delivery: Progress in Clinical and Preclinical Applications.
   Huda MN, Nafiujjaman M, Deaguero IG, Okonkwo J, et al · · 2021 · cited 160× · PMID 33988964 · DOI 10.1021/acsbiomaterials.1c00217
6. Clinical applications for exosomes: Are we there yet?
   Perocheau D, Touramanidou L, Gurung S, Gissen P, et al · · 2021 · cited 101× · PMID 33751579 · DOI 10.1111/bph.15432
7. Current advances in the use of exosomes, liposomes, and bioengineered hybrid nanovesicles in cancer detection and therapy.
   Mukherjee A, Bisht B, Dutta S, Paul MK. · · 2022 · cited 88× · PMID 35379933 · DOI 10.1038/s41401-022-00902-w
8. Extracellular vesicles as cancer liquid biopsies: from discovery, validation, to clinical application.
   Zhao Z, Fan J, Hsu YS, Lyon CJ, et al · · 2019 · cited 79× · PMID 30882822 · DOI 10.1039/c8lc01123k