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NCT03541265
Liposomal Bupivacaine in Total Knee Arthroplasty
NA trial testing Exparel in Knee Osteoarthritis in 70 participants. Completed in 1 March 2018.
1 June 2017
Quick facts
| Lead sponsor | Bronx-Lebanon Hospital Center Health Care System |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 70 |
| Start date | 1 May 2016 |
| Primary completion | 1 June 2017 |
| Estimated completion | 1 March 2018 |
Drugs / interventions tested
- Exparel — full drug profile →
- Adductor block protocol
- peri-articular injection protocol
Conditions studied
- Knee Osteoarthritis — all drugs for Knee Osteoarthritis →
- Anesthesia, Local — all drugs for Anesthesia, Local →
Sponsor
Bronx-Lebanon Hospital Center Health Care System
Who can join
25 and older, any sex, with Knee Osteoarthritis or Anesthesia, Local. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Pain management after total knee arthroplasty is essential for optimized clinical outcomes and higher satisfaction. Exparel (Pacira Pharmaceuticals, Parsippany, New Jersey, USA) is a long-acting Bupivacaine extended release liposome compound that is injected peri-articularly or as regional block. The purpose of this study was to compare the analgesic efficacy of single administration of Exparel for local peri-articular infiltration versus adductor canal regional block.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03541265
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Exparel
Trials testing the same drug.
- NCT06349772 — Zynrelef vs Exparel: The Battle of Postoperative Pain Control After Robotic Sleeve Gastrectomy · EARLY_PHASE1 · recruiting
- NCT06574022 — Post-mastectomy Recovery: Comparing Preoperative PECS-II Blocks With Intraoperative Pectoral Blocks · Phase 4 · recruiting
- NCT06619340 — EXPAREL IPSA Block in Knee Arthroplasty · Phase 4 · enrolling by invitation
- NCT06350981 — Analgesic Requirement for Post-Operative Pain Control in TLIP Interbody Fusion · Phase 2, PHASE3 · enrolling by invitation
- NCT06274008 — Exparel vs. ACB With Bupivacaine for ACL Reconstruction · Phase 1 · unknown
Other recruiting trials for Knee Osteoarthritis
Currently open trials in the same condition.
- NCT06906939 — A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression · EARLY_PHASE1 · recruiting
- NCT05823727 — Effects of Collagen Peptide Supplementation on Connective Tissue Remodeling, Functional Outcomes, and Wound Healing Afte · NA · recruiting
- NCT07370480 — Knee Osteoarthritis and Thermal Spa Treatment · NA · recruiting
- NCT07507175 — Gastrocnemius Myofascial Release in Females With Knee Osteoarthritis · NA · recruiting
- NCT07386600 — Dexamethasone vs Dexmedetomidine for iPACK + ACB in TKA · NA · recruiting
Other Bronx-Lebanon Hospital Center Health Care System trials
Trials by the same sponsor.
- NCT04421859 — Augmented Reality Mobile Application for Glaucoma Education in the South Bronx · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03541265 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Bronx-Lebanon Hospital Center Health Care System
- Last refreshed: 30 May 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03541265.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing