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NCT03535623
RIPC During Free Flap With Preoperative Radiotherapy
NA trial testing remote ischemic preconditioning (RIPC) in Ischemic Reperfusion Injury in 44 participants. Completed in 18 April 2024.
20 March 2024
Quick facts
| Lead sponsor | Seoul National University Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 44 |
| Start date | 29 May 2018 |
| Primary completion | 20 March 2024 |
| Estimated completion | 18 April 2024 |
| Sites | 1 location across South Korea |
Drugs / interventions tested
- remote ischemic preconditioning (RIPC)
- Sham-RIPC
Conditions studied
- Ischemic Reperfusion Injury — all drugs for Ischemic Reperfusion Injury →
- Other Reconstructive Surgery — all drugs for Other Reconstructive Surgery →
- Radiotherapy — all drugs for Radiotherapy →
Sponsor
Seoul National University Hospital
Who can join
20 and older, any sex, with Ischemic Reperfusion Injury or Other Reconstructive Surgery. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Remote ischemic preconditioning (RIPC) has shown organ-protective effects in many clinical settings including patients with ischemic heart disease. However its protective role in head and neck cancer patients with preoperative radiotherapy undergoing free flap reconstructive surgery has not yet been evaluated. The purpose of the current study is to evaluate the effect of RIPC on tissue oxygen saturation and skin temperature of the flap.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Ischemia-reperfusion injury in a rat microvascular skin free flap model: A histological, genetic, and blood flow study.
Ballestín A, Casado JG, Abellán E, Vela FJ, et al · · 2018 · cited 38× · PMID 30589864 · DOI 10.1371/journal.pone.0209624
Verify or expand the search:
- PubMed search for NCT03535623
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of remote ischemic preconditioning (RIPC)
Trials testing the same drug.
- NCT06312098 — Perioperative Factors and Living Donor Liver Transplantation · unknown
- NCT03474952 — Effects of Remote Ischemic Preconditioning During Free Flap Reconstruction · NA · completed
Other Seoul National University Hospital trials
Trials by the same sponsor.
- NCT07262944 — EOI Block in Otoplasty With Rib Cartilage Graft · NA · recruiting
- NCT07464210 — Nemtabrutinib, Bortezomib, and Rituximab for WM · Phase 2 · not yet recruiting
- NCT07550803 — Effect of Intraoperative Dexamethasone on Early Postoperative Sleep Quality in Patients Undergoing Nasal Surgery · NA · not yet recruiting
- NCT07522138 — Home-based Self-exercise in Patients With Parkinson's Disease: A Feasibility Study · NA · not yet recruiting
- NCT07476651 — Scout Dose of Resin Microspheres · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03535623 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Seoul National University Hospital
- Last refreshed: 7 May 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03535623.
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