NCT03534154 (BIO-AX-TBI) is a clinical trial of MRI in Traumatic Brain Injury, sponsored by Imperial College London.

Who is sponsoring NCT03534154?

NCT03534154 is sponsored by Imperial College London.

What drugs are being tested in NCT03534154?

Interventions in NCT03534154: MRI, Blood Sampling, Microdialysis, Neuropsychological tests, MRI (advanced).

What condition does NCT03534154 study?

NCT03534154 studies Traumatic Brain Injury.

Is NCT03534154 still recruiting?

NCT03534154 is currently completed. Last updated 31 March 2022.

Last reviewed 2022-03-31 · How we verify

NCT03534154: BIO-AX-TBI

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Developing and Validating Blood and Imaging BIOmarkers of AXonal Injury Following Traumatic Brain Injury

Completed Last updated 31 March 2022

What this trial tests

trial testing MRI in Traumatic Brain Injury in 313 participants. Completed in 30 December 2021.

Timeline

30 November 2017

Primary endpoint
30 April 2021

30 December 2021

Quick facts

Lead sponsor	Imperial College London
Status	Completed
Study type	OBSERVATIONAL
Enrollment	313
Start date	30 November 2017
Primary completion	30 April 2021
Estimated completion	30 December 2021
Sites	5 locations across Switzerland, Italy, United Kingdom, Slovenia

Drugs / interventions tested

MRI — full drug profile →
Blood Sampling — full drug profile →
Microdialysis
Neuropsychological tests
MRI (advanced)

Conditions studied

Traumatic Brain Injury — all drugs for Traumatic Brain Injury →

Sponsor

Imperial College London

Who can join

Adults 18 to 80, any sex, with Traumatic Brain Injury. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Observational longitudinal study assessing outcomes following moderate-severe traumatic brain injury (TBI).

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Multicentre longitudinal study of fluid and neuroimaging BIOmarkers of AXonal injury after traumatic brain injury: the BIO-AX-TBI study protocol.
Graham NSN, Zimmerman KA, Bertolini G, Magnoni S, et al · · 2020 · cited 17× · PMID 33172948 · DOI 10.1136/bmjopen-2020-042093
Preservation of anticorrelated brain networks predicts recovery after traumatic brain injury.
Snider SB, Shi H, Bodien YG, Howard C, et al · · 2025 · cited 1× · PMID 41428880 · DOI 10.1073/pnas.2518159122
Investigating the characteristics and correlates of systemic inflammation after traumatic brain injury: the TBI-BraINFLAMM study.
Li LM, Heslegrave A, Soreq E, Nattino G, et al · · 2023 · cited 1× · PMID 37221026 · DOI 10.1136/bmjopen-2022-069594

Verify or expand the search:

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Other recruiting trials for Traumatic Brain Injury

Currently open trials in the same condition.

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NCT07473505 — Integrative Bilateral Cervical Sympathetic Blocks for Trauma-Related Symptoms in Special Operations Veterans: A Prospect · recruiting
NCT07455136 — A Study to Develop a Blood-based Test for Aiding the Diagnosis/Prognosis of Traumatic Brain Injury in Adults and for Mon · recruiting
NCT07404761 — Safety and Effectiveness of Spatial StimelMD (SSMD) in Subjects With Upper Limb Neuromotor Impairments · NA · recruiting
NCT07230002 — Effects of Moderate/Severe Traumatic Brain Injury in the Subacute or Chronic Phase on Locomotor Strategies Involved in N · NA · recruiting

Other Imperial College London trials

Trials by the same sponsor.

NCT06035861 — Endothelial Cell Activation and Total Pulmonary Resistance in PAH · NA · not yet recruiting
NCT07397455 — Development of a Controlled Human Infection Model for Assessment of SARS-CoV-2 Omicron Subvariants · Phase 1 · not yet recruiting
NCT07422532 — A Multi-centre Trial to Assess the Efficacy and Safety of the Omnipod 5 System in People With Type 2 Diabetes Undergoing · NA · not yet recruiting
NCT07389031 — Maralixibat for Intrahepatic Cholestasis of Pregnancy · Phase 2 · not yet recruiting
NCT07358897 — Gender Affirming Hormone Therapy and Immune Function in Trans Individuals - The GIFT Study · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03534154 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Imperial College London
Last refreshed: 31 March 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03534154.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing