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NCT03530358: MOSE

MOdularity for SEnsory Motor Control

Status unknown NA Last updated 8 June 2022
What this trial tests

NA trial testing Technology-aided rehabilitation in Stroke, Ischemic in 132 participants. Status unknown.

Timeline
1 December 2014
Primary endpoint
1 December 2018
1 December 2022

Quick facts

Lead sponsorIRCCS San Camillo, Venezia, Italy
PhaseNA
StatusStatus unknown
Study typeINTERVENTIONAL
Allocationrandomized
Designparallel
Maskingdouble
Primary purposetreatment
Enrollment132
Start date1 December 2014
Primary completion1 December 2018
Estimated completion1 December 2022
Sites2 locations across Italy

Drugs / interventions tested

Conditions studied

Sponsor

IRCCS San Camillo, Venezia, Italy

Who can join

18 and older, any sex, with Stroke, Ischemic or Upper Limb Injury. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

For this project the investigators ask, how the activation and organization of muscle synergies may be disrupted by brain lesions, and whether it is possible to modify synergy activations by means of specific therapies. Will be investigated whether there is a relationship between post-stroke cortical plasticity and changes in synergy activations due to a therapy.

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Effects of robot therapy on upper body kinematics and arm function in persons post stroke: a pilot randomized controlled trial.
    Carpinella I, Lencioni T, Bowman T, Bertoni R, et al · · 2020 · cited 32× · PMID 32000790 · DOI 10.1186/s12984-020-0646-1
  2. A randomized controlled trial on the effects induced by robot-assisted and usual-care rehabilitation on upper limb muscle synergies in post-stroke subjects.
    Lencioni T, Fornia L, Bowman T, Marzegan A, et al · · 2021 · cited 31× · PMID 33674675 · DOI 10.1038/s41598-021-84536-8
  3. Muscle Synergies and Clinical Outcome Measures Describe Different Factors of Upper Limb Motor Function in Stroke Survivors Undergoing Rehabilitation in a Virtual Reality Environment.
    Maistrello L, Rimini D, Cheung VCK, Pregnolato G, et al · · 2021 · cited 16× · PMID 34884003 · DOI 10.3390/s21238002
  4. Surface-Electromyography-Based Co-Contraction Index for Monitoring Upper Limb Improvements in Post-Stroke Rehabilitation: A Pilot Randomized Controlled Trial Secondary Analysis.
    Bandini V, Carpinella I, Marzegan A, Jonsdottir J, et al · · 2023 · cited 12× · PMID 37687775 · DOI 10.3390/s23177320
  5. Muscle Synergy Analysis for Clinical Characterization of Upper Limb Motor Recovery After Stroke.
    Pregnolato G, Severini G, Maistrello L, Rimini D, et al · · 2026 · cited 3× · PMID 40484193 · DOI 10.1016/j.apmr.2025.05.019
  6. Characterization of motor function recovery using muscle synergies in stroke patients undergoing upper limb rehabilitation
    Pregnolato G, Severini G, Maistrello L, Rimini D, et al · · 2024 · DOI 10.1101/2024.09.24.24314287

Verify or expand the search:

Other recruiting trials for Stroke, Ischemic

Currently open trials in the same condition.

Other IRCCS San Camillo, Venezia, Italy trials

Trials by the same sponsor.

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Data sources for this page

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