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NCT03530072
Use of NGS Cell-free Pathogen Test for Identification of Low Risk Fever & Neutropenia in Pediatric Patients
trial testing Karius Test in Neutropenia in 15 participants. Completed in 31 October 2019.
1 August 2019
Quick facts
| Lead sponsor | Karius, Inc. |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 15 |
| Start date | 7 May 2018 |
| Primary completion | 1 August 2019 |
| Estimated completion | 31 October 2019 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Karius Test
Conditions studied
- Neutropenia — all drugs for Neutropenia →
- Fever — all drugs for Fever →
Sponsor
Karius, Inc.
Who can join
Adults 1 to 22, any sex, with Neutropenia or Fever. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Febrile neutropenia is a common complication in pediatric oncology patients. Standard of care requires admission of all patients for intravenous antibiotics until cultures are negative, patients are afebrile and there are signs of bone marrow recovery. This often results in prolonged hospital admissions with significant financial costs, decreased quality of life and potential secondary infections. More recent data suggests it may be possible to identify a "low risk" group that can be discharged prior to signs of bone marrow recovery. At this time, researchers have been unable to identify a model that is safe for early discharge across institutions.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03530072
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Karius Test
Trials testing the same drug.
- NCT04047719 — Pneumonia in the ImmunoCompromised - Use of the Karius Test for the Detection of Undiagnosed Pathogens · completed
- NCT03846804 — Next-Generation Sequencing for Pathogen Detection and Quantification in Children With Musculoskeletal Infections · NA · completed
Other recruiting trials for Neutropenia
Currently open trials in the same condition.
- NCT07434063 — Real-world Study on the Prevention of Neutropenia After Tumor Treatment With Mecapegfilgrastim Injection · recruiting
- NCT07066085 — Serial Blood Count Study · EARLY_PHASE1 · recruiting
- NCT06537726 — Breath Analysis for the Detection of Invasive Fungal Infections · recruiting
- NCT06145321 — Continuous Versus Bolus Administration of G-CSF in Children With Cancer · Phase 4 · active not recruiting
- NCT06422533 — Ceftolozane/Tazobactam vs. Piperacillin/Tazobactam for the Treatment of Bacteremia in Hemato-oncological Patients · NA · recruiting
Other Karius, Inc. trials
Trials by the same sponsor.
- NCT07110636 — Microbial Cell-free Metagenomic Sequencing for Suspected Infections in Adult Immunocompromised Outpatients · NA · recruiting
- NCT04047719 — Pneumonia in the ImmunoCompromised - Use of the Karius Test for the Detection of Undiagnosed Pathogens · completed
- NCT03262584 — Evaluation of NGS for Detection and Follow-up of Fungal Pathogens in Immunocompromised Pediatric Patients · completed
- NCT03620487 — Detection of Dengue Virus in Plasma of Patients in Nepal · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03530072 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Karius, Inc.
- Last refreshed: 10 February 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03530072.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing