NCT03528031: HAT

Habitual Diet and Avocado Trial

Completed NA Last updated 22 March 2023

What this trial tests

NA trial testing Intervention Daily Avocado in Intra-abdominal Fat in 1,008 participants. Completed in 30 October 2020.

Timeline

19 June 2018

Primary endpoint
16 October 2020

30 October 2020

Quick facts

Lead sponsor	Wake Forest University Health Sciences
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	1,008
Start date	19 June 2018
Primary completion	16 October 2020
Estimated completion	30 October 2020
Sites	4 locations across United States

Drugs / interventions tested

• Intervention Daily Avocado

Conditions studied

• Intra-abdominal Fat — all drugs for Intra-abdominal Fat →
• Metabolic Syndrome — all drugs for Metabolic Syndrome →
• High Cholesterol — all drugs for High Cholesterol →
• Triglycerides High — all drugs for Triglycerides High →

Sponsor

Wake Forest University Health Sciences

Who can join

25 and older, any sex, with Intra-abdominal Fat or Metabolic Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The Habitual Diet and Avocado Trial will evaluate the effects of providing one avocado per day for recommended consumption over a 6 month period in a cohort of approximately 1000 free-living participants with increased waist circumference in comparison with a control group that will maintain their habitual diets. Participants will be recruited and screened at 4 clinics in 4 locations: Pennsylvania State University; Loma Linda University; UCLA, and Tufts University (250 per site).

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Effect of Incorporating 1 Avocado Per Day Versus Habitual Diet on Visceral Adiposity: A Randomized Trial.
   Lichtenstein AH, Kris-Etherton PM, Petersen KS, Matthan NR, et al · · 2022 · cited 20× · PMID 35861827 · DOI 10.1161/jaha.122.025657
2. Effect of daily avocado consumption for 6 mo compared with habitual diet on red blood cell fatty acid profiles and association with cardiometabolic risk factors in individuals with abdominal obesity: a randomized trial.
   Matthan NR, Lovato L, Petersen KS, Kris-Etherton PM, et al · · 2024 · cited 5× · PMID 39128497 · DOI 10.1016/j.ajcnut.2024.08.002
3. Effect of Incorporating 1 Avocado per Day Versus Habitual Diet on Vascular Function in Adults With Abdominal Obesity: An Ancillary Study of HAT, a Randomized Controlled Trial.
   Davis KM, Petersen KS, Matthan NR, Legro RS, et al · · 2024 · cited 5× · PMID 38726886 · DOI 10.1161/jaha.123.030497
4. One Avocado per Day as Part of Usual Intake Improves Diet Quality: Exploratory Results from a Randomized Controlled Trial.
   Petersen KS, Smith S, Lichtenstein AH, Matthan NR, et al · · 2024 · cited 5× · PMID 38375072 · DOI 10.1016/j.cdnut.2024.102079
5. Automated abdominal adipose tissue segmentation and volume quantification on longitudinal MRI using 3D convolutional neural networks with multi-contrast inputs.
   Kafali SG, Shih SF, Li X, Kim GHJ, et al · · 2024 · cited 4× · PMID 38300360 · DOI 10.1007/s10334-023-01146-3
6. The Effect of Daily Avocado Intake on Food and Nutrient Displacement in a Free-Living Population with Abdominal Obesity.
   Clarke AE, LeBeau KS, Oda K, Segovia-Siapco G, et al · · 2024 · cited 3× · PMID 39886351 · DOI 10.1016/j.cdnut.2024.104451
7. Impact of daily avocado consumption on gut microbiota in adults with abdominal obesity: an ancillary study of HAT, a randomized controlled trial.
   Yang J, Lei OK, Bhute S, Kris-Etherton PM, et al · · 2025 · cited 3× · PMID 39641169 · DOI 10.1039/d4fo03806a
8. Exploring avocado consumption and health: a scoping review and evidence map.
   Fleming SA, Paul TL, Fleming RAF, Ventura AK, et al · · 2025 · cited 1× · PMID 39996010 · DOI 10.3389/fnut.2025.1488907