NCT03526653

Physical and Cognitive Exercises in Nursing Homes: Is Frailty Reversible?

Completed NA Last updated 21 November 2019

What this trial tests

NA trial testing exercise without visual stimuli in Physical Activity in 10 participants. Completed in 1 June 2018.

Timeline

1 April 2018

Primary endpoint
1 June 2018

1 June 2018

Quick facts

Lead sponsor	Hasselt University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	crossover
Masking	single
Primary purpose	screening
Enrollment	10
Start date	1 April 2018
Primary completion	1 June 2018
Estimated completion	1 June 2018
Sites	1 location across Belgium

Drugs / interventions tested

• exercise without visual stimuli
• excercise with National Geografics
• Exercise with MemoRide

Conditions studied

• Physical Activity — all drugs for Physical Activity →
• Elderly — all drugs for Elderly →

Sponsor

Hasselt University

Who can join

70 and older, any sex, with Physical Activity or Elderly. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Elderly in residential care spend 97% of their time sedentary. Moreover, exercise therapy often takes place in a poorly stimulating environment which is less motivational for the elderly to undertake regularly. Exercise is however necessary to preserve their physical capabilities and to limit their care dependence.

The aim of this study is to investigate the most motivating and stimulating exercise modality for prefrail and frail elderly in nursing homes with which they can reach sufficient training volume.

To study this, elderly will exercise in 3 different ways on an ergometer or motomed (according to their physical capabilities): 1) in an environment without other visual stimuli 2) in front of a television with National Geographic images 3) with the interactive software program MemoRide with which participants can exercise in real life on a virtual manner.

MemoRide (Activ84Health) uses Google Street View images. The starting point is a connection between an exercise bike and a tablet with a pedalling sensor. This way, pedal frequency is sent to the tablet and as a result, images continue when pedalling.

The forth modality is the control modality, in which participants are instructed to rest (supine) during 30 minutes.

Based on objective training parameters and metabolic parameters e.g. glucose, insulin, brain-derived neurotrophic factor (BDNF) and lactate, (via a blood sample with a venous catheter) the training modality which offers the best training results will be studied. Secondly, also subject experiences (motivation and emotions) will be evaluated by using questionnaires and observation scales.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Physical Activity and Frailty Are Impaired in Older Adults with Benign Paroxysmal Positional Vertigo.
   Pauwels S, Lemkens N, Lemmens W, Meijer K, et al · · 2024 · cited 3× · PMID 39768460 · DOI 10.3390/jcm13247542
2. Co-Existing Vestibular Hypofunction Impairs Postural Control, but Not Frailty and Well-Being, in Older Adults with Benign Paroxysmal Positional Vertigo.
   Pauwels S, Lemkens N, Lemmens W, Meijer K, et al · · 2025 · PMID 40283496 · DOI 10.3390/jcm14082666