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NCT03526042
Angiotensin-II Receptor Antibodies Blockade With Losartan in Patients With Lupus Nephritis
NA trial testing Losartan in Atherosclerosis in 40 participants. Status unknown.
31 July 2019
Quick facts
| Lead sponsor | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 40 |
| Start date | 10 September 2017 |
| Primary completion | 31 July 2019 |
| Estimated completion | 31 October 2019 |
| Sites | 1 location across Mexico |
Drugs / interventions tested
Conditions studied
- Atherosclerosis — all drugs for Atherosclerosis →
- Lupus Nephritis — all drugs for Lupus Nephritis →
Sponsor
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran — full company profile →
Who can join
Adults 16 to 50, any sex, with Atherosclerosis or Lupus Nephritis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Antibodies directed against angiotensin-II receptor (AT1-Ab) are agonist antibodies previously studied in human diseases such as preeclampsia, transplantation and scleroderma. They act by binding to the AT1 receptor and their effects can be blocked with the use of angiotensin receptor blockers (ARB). In this randomized open clinical trial the investigators will study the effect of the blockade of AT1-Ab with losartan in carotid intima-media thickness progression in patients with lupus nephritis compared to patients treated with enalapril.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT03526042
- Europe PMC full search
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- ESMO Meeting Library
- bioRxiv preprints
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03526042 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
- Last refreshed: 16 May 2018
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