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NCT03524690
Effects of Severe Negative Energy Balance on Inflammation
NA trial testing Energy Balance in Inflammation in 13 participants. Completed in 8 October 2019.
8 October 2019
Quick facts
| Lead sponsor | United States Army Research Institute of Environmental Medicine |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 13 |
| Start date | 13 February 2019 |
| Primary completion | 8 October 2019 |
| Estimated completion | 8 October 2019 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Energy Balance
- Negative Energy Balance
Conditions studied
- Inflammation — all drugs for Inflammation →
Sponsor
United States Army Research Institute of Environmental Medicine
Who can join
Adults 18 to 39, male only, with Inflammation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The effects of prolonged negative energy balance, commonly observed in sustained military training and combat operations, on systemic inflammatory responses has not been determined. To define the putative role of energy balance on inflammation and its downstream effects, we will conduct a controlled laboratory study that simulates extensive physiological stressors to determine if inflammation is exacerbated by underfeeding. This design will test the hypothesis that maintaining energy balance will attenuate systemic inflammation and its potential negative effects on whole-body metabolic homeostasis in response to physiological stressors.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Energy deficit increases hepcidin and exacerbates declines in dietary iron absorption following strenuous physical activity: a randomized-controlled cross-over trial.
Hennigar SR, McClung JP, Hatch-McChesney A, Allen JT, et al · · 2021 · cited 33× · PMID 33184627 · DOI 10.1093/ajcn/nqaa289
Verify or expand the search:
- PubMed search for NCT03524690
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Energy Balance
Trials testing the same drug.
- NCT05203133 — Effects of Acute Energy Deficit and Aerobic Exercise on Muscle Quality · NA · completed
- NCT03600311 — Resistance Exercise and Protein During Weight Loss · NA · completed
- NCT03301948 — Effects of a Single Day of Mixed Macronutrient Overfeeding on Energy Balance and Metabolic Responses · NA · completed
Other recruiting trials for Inflammation
Currently open trials in the same condition.
- NCT07341087 — Skin Inflammation in Perimenopause: A Probiotic Intervention Proof of Concept Trial · NA · recruiting
- NCT07479940 — Obesity and Aging: Impacts of Nutritional Counseling and Physical Exercise on Telomeres and Senescence Parameters · NA · active not recruiting
- NCT07269847 — Comparing a Healthy Beef-Centric Diet to a Healthy U.S.-Style Diet on Metabolic Health Outcomes in Pre-Diabetic Adults · NA · recruiting
- NCT07171450 — Cognitive Remediation · NA · recruiting
- NCT07411612 — The Association Between Postoperative Inflammatory and Neurological Serum Biomarker Concentrations and Occurrence of Pos · recruiting
Other United States Army Research Institute of Environmental Medicine trials
Trials by the same sponsor.
- NCT07489690 — Energy Dense Fueling for Cold-Weather Operations · NA · recruiting
- NCT07099872 — Chronic Exercise With Overdressing · NA · completed
- NCT06468748 — The Effects of Semaglutide on Body Composition and Performance in Military Personnel · Phase 4 · withdrawn
- NCT07063173 — Bioavailability of Ration Items Containing Tart Cherry Extract · NA · recruiting
- NCT06073080 — Recovery Protein Nutrition as a Countermeasure for Anabolic Resistance Following Sleep Loss · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03524690 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by United States Army Research Institute of Environmental Medicine
- Last refreshed: 22 April 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03524690.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing