NCT03523325: ATX

Achilles Tendinopathy, Treatment With eXercise Comparing Men and Women

Completed NA Last updated 27 June 2024

What this trial tests

NA trial testing Exercise treatment in Achilles Tendinopathy in 182 participants. Completed in 12 March 2024.

Timeline

2 July 2018

Primary endpoint
12 January 2024

12 March 2024

Quick facts

Lead sponsor	University of Delaware
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	182
Start date	2 July 2018
Primary completion	12 January 2024
Estimated completion	12 March 2024
Sites	1 location across United States

Drugs / interventions tested

• Exercise treatment

Conditions studied

• Achilles Tendinopathy — all drugs for Achilles Tendinopathy →
• Achilles Tendonitis — all drugs for Achilles Tendonitis →
• Achilles Tendon Pain — all drugs for Achilles Tendon Pain →
• Achilles Degeneration — all drugs for Achilles Degeneration →

Sponsor

University of Delaware

Who can join

Adults 18 to 65, any sex, with Achilles Tendinopathy or Achilles Tendonitis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study will evaluate if there is a difference in recovery of tendon structure and mechanical properties between males and females with Achilles tendinopathy receiving exercise treatment. It will evaluate recovery of tendinopathy with exercise intervention using outcome measures for tendon structure and mechanical properties along with validated measures of muscle-tendon function and symptoms.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Effect of Symptom Duration on Injury Severity and Recovery in Patients With Achilles Tendinopathy.
   Hanlon SL, Scattone Silva R, Honick BJ, Silbernagel KG. · · 2023 · cited 7× · PMID 37250747 · DOI 10.1177/23259671231164956
2. Differences in Recovery of Tendon Health Explained by Midportion Achilles Tendinopathy Subgroups: A 6-Month Follow-up.
   Hanlon SL, Pohlig RT, Silbernagel KG. · · 2023 · cited 7× · PMID 36688719 · DOI 10.2519/jospt.2023.11330
3. Is the VISA-A Still Seaworthy, or Is It in Need of Maintenance?
   Sigurðsson HB, Grävare Silbernagel K. · · 2022 · cited 6× · PMID 35982828 · DOI 10.1177/23259671221108950
4. Data driven model of midportion achilles tendinopathy health created with factor analysis.
   Sigurðsson HB, Couppé C, Silbernagel KG. · · 2022 · cited 5× · PMID 35922770 · DOI 10.1186/s12891-022-05702-1
5. Putting the fear-avoidance model into practice - what can patients with chronic low back pain learn from patients with Achilles tendinopathy and vice versa?
   Smitheman HP, Lundberg M, Härnesand M, Gelfgren S, et al · · 2023 · cited 4× · PMID 37952338 · DOI 10.1016/j.bjpt.2023.100557
6. Relationship Between Structure and Age in Healthy Achilles Tendons.
   Seymore KD, Hanlon SL, Pohlig RT, Elliott DM, et al · · 2025 · cited 2× · PMID 40170276 · DOI 10.1002/jor.26080
7. Analysis of Regional Heterogeneity of Mechanical Properties Improves Sensitivity of Elastography to Changes With Achilles Tendinopathy.
   Dunay GL, Seymore KD, Grävare Silbernagel K, Cone SG. · · 2026 · cited 1× · PMID 40539868 · DOI 10.1002/jor.70008
8. Metabolic Risk Factors Relate to Worse Tendon Health in Individuals With Achilles Tendinopathy.
   Seymore KD, Smitheman HP, Smith AK, Pohlig RT, et al · · 2025 · cited 1× · PMID 39763090 · DOI 10.1002/jor.26038