NCT03522103 (COSMIC) is a clinical trial in Inflammation, sponsored by University of Colorado, Denver.

Who is sponsoring NCT03522103?

NCT03522103 is sponsored by University of Colorado, Denver.

What condition does NCT03522103 study?

NCT03522103 studies Inflammation, Inflammatory Response, Mood, Cognitive Change.

Is NCT03522103 still recruiting?

NCT03522103 is currently completed. Last updated 12 July 2021.

Last reviewed 2021-07-12 · How we verify

NCT03522103: COSMIC

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Cannabis Observational Study on Mood, Inflammation, and Cognition

Completed Last updated 12 July 2021

What this trial tests

trial in Inflammation in 421 participants. Completed in 15 December 2020.

Timeline

1 July 2016

Primary endpoint
15 December 2020

15 December 2020

Quick facts

Lead sponsor	University of Colorado, Denver
Status	Completed
Study type	OBSERVATIONAL
Enrollment	421
Start date	1 July 2016
Primary completion	15 December 2020
Estimated completion	15 December 2020
Sites	1 location across United States

Conditions studied

Inflammation — all drugs for Inflammation →
Inflammatory Response — all drugs for Inflammatory Response →
Mood — all drugs for Mood →
Cognitive Change — all drugs for Cognitive Change →

Sponsor

University of Colorado, Denver

Who can join

Adults 21 to 70, any sex, with Inflammation or Inflammatory Response. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This project examines the effects of cannabis on cognition and other domains of function and whether those effects are dependent upon the ratio of THC to CBD in the product. Current cannabis users are asked to stop using their typical product and to use cannabis containing different ratios of the cannabinoids THC and CBD. Participants complete baseline assessments including cognitive tasks, clinical measures, substance use history, and blood draw. Participants then acquire and use their study strain on their own, and after a period of use the mobile pharmacology laboratory goes to a location of their choosing. They complete cognitive, motor and blood-based assessments, then leave the mobile lab to use their study product one last time, returning to the mobile lab to complete cognitive, motor, and blood-based assessments immediately after use and one hour after use. A small subset of participants complete all of these procedures but use edible as opposed to flower-based products.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

<i>Cannabis</i>, the Endocannabinoid System and Immunity-the Journey from the Bedside to the Bench and Back.
Almogi-Hazan O, Or R. · · 2020 · cited 89× · PMID 32585801 · DOI 10.3390/ijms21124448
Association of Naturalistic Administration of Cannabis Flower and Concentrates With Intoxication and Impairment.
Bidwell LC, Ellingson JM, Karoly HC, YorkWilliams SL, et al · · 2020 · cited 69× · PMID 32520316 · DOI 10.1001/jamapsychiatry.2020.0927
Effects of High-Potency Cannabis on Psychomotor Performance in Frequent Cannabis Users.
Karoly HC, Milburn MA, Brooks-Russell A, Brown M, et al · · 2022 · cited 24× · PMID 33998859 · DOI 10.1089/can.2020.0048
Cannabinoid Exposure and Subjective Effects of THC and CBD in Edible Cannabis Products.
Gibson LP, Mueller RL, Winiger EA, Klawitter J, et al · · 2024 · cited 9× · PMID 36378267 · DOI 10.1089/can.2022.0020
Investigating the Relationship Between Cannabis Expectancies and Anxiety, Depression, and Pain Responses After Acute Flower and Edible Cannabis Use.
Chen MY, Kramer EB, Gibson LP, Bidwell LC, et al · · 2025 · cited 3× · PMID 38608236 · DOI 10.1089/can.2023.0264

Verify or expand the search:

Other recruiting trials for Inflammation

Currently open trials in the same condition.

NCT07341087 — Skin Inflammation in Perimenopause: A Probiotic Intervention Proof of Concept Trial · NA · recruiting
NCT07479940 — Obesity and Aging: Impacts of Nutritional Counseling and Physical Exercise on Telomeres and Senescence Parameters · NA · active not recruiting
NCT07269847 — Comparing a Healthy Beef-Centric Diet to a Healthy U.S.-Style Diet on Metabolic Health Outcomes in Pre-Diabetic Adults · NA · recruiting
NCT07171450 — Cognitive Remediation · NA · recruiting
NCT07411612 — The Association Between Postoperative Inflammatory and Neurological Serum Biomarker Concentrations and Occurrence of Pos · recruiting

Other University of Colorado, Denver trials

Trials by the same sponsor.

NCT07292285 — The Surveillance Nonoperative Watch & Wait (SNOWW) Rectal Cancer Trial. · not yet recruiting
NCT07021937 — Brain Plasticity and GLP-1 Receptor Agonist Treatment for Obesity · Phase 3 · not yet recruiting
NCT07453732 — Banana Leaves as a Wound Dressing for Partial Thickness Second Degree Burns in Adult Patients. · NA · not yet recruiting
NCT07038278 — 5-AminoLevulinic Acid Aided Resection Margins in Sarcoma · EARLY_PHASE1 · not yet recruiting
NCT07279558 — Cannabidiol and Alcohol Use Disorder Phenotypes · Phase 2 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03522103 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Colorado, Denver
Last refreshed: 12 July 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03522103.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing