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NCT03520894: ROCK
Radiotherapy in Preoperative Setting With CyberKnife for Breast Cancer
NA trial testing Neoadjuvant radiotherapy in Early Breast Cancer in 25 participants. Status unknown.
1 May 2022
Quick facts
| Lead sponsor | Azienda Ospedaliero-Universitaria Careggi |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 25 |
| Start date | 1 May 2018 |
| Primary completion | 1 May 2022 |
| Estimated completion | 1 May 2024 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Neoadjuvant radiotherapy
Conditions studied
- Early Breast Cancer — all drugs for Early Breast Cancer →
Sponsor
Azienda Ospedaliero-Universitaria Careggi — full company profile →
Who can join
50 and older, female only, with Early Breast Cancer. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of this study is to prospectively evaluate, in patients affected by early breast cancer, safety and feasibility of single fraction radiotherapy with Cyberknife R in preoperative setting, and to identify factors predictive for outcome based on biologic and clinical parameters.
Publications & conference data
5 peer-reviewed publications reference this trial (live from Europe PMC):
-
Preoperative robotic radiosurgery for early breast cancer: Results of the phase II ROCK trial (NCT03520894).
Meattini I, Francolini G, Di Cataldo V, Visani L, et al · · 2022 · cited 22× · PMID 36177053 · DOI 10.1016/j.ctro.2022.09.004 -
Recent Advances in Optimizing Radiation Therapy Decisions in Early Invasive Breast Cancer.
Riaz N, Jeen T, Whelan TJ, Nielsen TO. · · 2023 · cited 16× · PMID 36831598 · DOI 10.3390/cancers15041260 -
Prediction of pathologic complete response after single-dose MR-guided partial breast irradiation in low-risk breast cancer patients: the ABLATIVE-2 trial-a study protocol.
Civil YA, Oei AL, Duvivier KM, Bijker N, et al · · 2023 · cited 15× · PMID 37161377 · DOI 10.1186/s12885-023-10910-6 -
Single fraction ablative preoperative radiation treatment for early-stage breast cancer: the CRYSTAL study - a phase I/II clinical trial protocol.
Zerella MA, Zaffaroni M, Ronci G, Dicuonzo S, et al · · 2022 · cited 14× · PMID 35366825 · DOI 10.1186/s12885-022-09305-w -
Abstracts from the ASMIRT 2026 Conference, 26-29 March 2026, Hobart.
· 2026 · PMID 41821386 · DOI 10.1002/jmrs.70065
Verify or expand the search:
- PubMed search for NCT03520894
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Currently open trials in the same condition.
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Other Azienda Ospedaliero-Universitaria Careggi trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03520894 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Azienda Ospedaliero-Universitaria Careggi
- Last refreshed: 22 October 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03520894.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing