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Tissue-nonspecific Alkaline Phosphatase in Phosphate and Pyrophosphate Homeostasis. (PIPAL)
Vascular calcification is a common finding in chronic kidney disease and increases arterial stiffness leading to augmented cardiovascular morbidity. The calcification process is thoroughly regulated by pro and anticalcifying agents. The investigators hypothesize that imbalance in these compounds could depend on alkaline phosphatase activity. Therefore, the investigators will measure ALP activity, calcifications score, arterial stiffness and perform a bio-collection in monogenic rare diseases characterized by various levels of anticalcifying agents and in diverse CKD stages characterized by various levels of procalcifying compounds.
Details
| Lead sponsor | Centre Hospitalier Universitaire de Nice |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 35 |
| Start date | Tue May 15 2018 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Fri Sep 06 2019 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Chronic Kidney Disease
Interventions
- Blood samples
- Urinary samples
Countries
France