NCT03520452 is a NA clinical trial of Green coffee extract in Endothelial Dysfunction, sponsored by Société des Produits Nestlé (SPN).

Who is sponsoring NCT03520452?

NCT03520452 is sponsored by Société des Produits Nestlé (SPN).

What drugs are being tested in NCT03520452?

Interventions in NCT03520452: Green coffee extract, Placebo.

What condition does NCT03520452 study?

NCT03520452 studies Endothelial Dysfunction.

Is NCT03520452 still recruiting?

NCT03520452 is currently completed. Last updated 15 January 2019.

Last reviewed 2019-01-15 · How we verify

NCT03520452

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Chlorogenic Acids on the Human Vasculature

Completed NA Last updated 15 January 2019

What this trial tests

NA trial testing Green coffee extract in Endothelial Dysfunction in 22 participants. Completed in 20 December 2018.

Timeline

14 March 2018

Primary endpoint
7 November 2018

20 December 2018

Quick facts

Lead sponsor	Société des Produits Nestlé (SPN)
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	quadruple
Primary purpose	other
Enrollment	22
Start date	14 March 2018
Primary completion	7 November 2018
Estimated completion	20 December 2018
Sites	1 location across Australia

Drugs / interventions tested

Green coffee extract
Placebo

Conditions studied

Endothelial Dysfunction — all drugs for Endothelial Dysfunction →

Sponsor

Société des Produits Nestlé (SPN) — full company profile →

Who can join

Adults 45 to 65, any sex, with Endothelial Dysfunction. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study evaluates effects of different doses of chlorogenic acids on vascular health.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Potential Benefits of Black Chokeberry (<i>Aronia melanocarpa</i>) Fruits and Their Constituents in Improving Human Health.
Ren Y, Frank T, Meyer G, Lei J, et al · · 2022 · cited 42× · PMID 36431924 · DOI 10.3390/molecules27227823
Acute dose-response effect of coffee-derived chlorogenic acids on the human vasculature in healthy volunteers: a randomized controlled trial.
Naylor LH, Zimmermann D, Guitard-Uldry M, Poquet L, et al · · 2021 · cited 18× · PMID 33330899 · DOI 10.1093/ajcn/nqaa312

Verify or expand the search:

Other trials of Green coffee extract

Trials testing the same drug.

NCT05009615 — Efficacy of Hydroxycinnamates and Beta-glucans as a Dietary Tool Against Obesity (OBHEALTH) · NA · completed

Other recruiting trials for Endothelial Dysfunction

Currently open trials in the same condition.

NCT07487363 — TB-500 (Thymosin Beta 4 17-23 Fragment) for Cardiovascular Biomarkers in Stable ASCVD · Phase 1, PHASE2 · recruiting
NCT07422974 — Perioperative Outcomes After Neoadjuvant Therapy in Colorectal Cancer · recruiting
NCT06419959 — NightWare and Cardiovascular Health in Veterans With PTSD · NA · recruiting
NCT07227727 — Endothelial Dysfunction After SCI · recruiting
NCT07227740 — Testosterone Deficiency and Endothelial Dysfunction After Spinal Cord Injury · recruiting

Other Société des Produits Nestlé (SPN) trials

Trials by the same sponsor.

NCT07312201 — Oral Nutritional Supplementation in Children With Growth Concerns · NA · not yet recruiting
NCT07378111 — Vegetarian Tube Feed Study · NA · not yet recruiting
NCT07439718 — The Effects of an Oral Nutritional Intervention on the Small Intestine Microbiome · NA · recruiting
NCT07341464 — Acceptability and Tolerance Study of Bolus Tube Feed With Food Blends · NA · recruiting
NCT07127198 — Tolerance and Appetite Reduction of a Nutritional Solution With Intragastric Gelation Properties · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03520452 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Société des Produits Nestlé (SPN)
Last refreshed: 15 January 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03520452.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing