NCT03520244: MOVE-C

A 12-week Exercise Program for Adults With Celiac Disease

Completed NA Last updated 28 September 2018

What this trial tests

NA trial testing Exercise + Holistic Education in Celiac Disease in 48 participants. Completed in 30 March 2018.

Timeline

15 November 2016

Primary endpoint
30 March 2018

30 March 2018

Quick facts

Lead sponsor	University of Calgary
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	supportive care
Enrollment	48
Start date	15 November 2016
Primary completion	30 March 2018
Estimated completion	30 March 2018
Sites	1 location across Canada

Drugs / interventions tested

• Exercise + Holistic Education

Conditions studied

• Celiac Disease — all drugs for Celiac Disease →

Sponsor

University of Calgary

Who can join

18 and older, any sex, with Celiac Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Engagement in regular physical activity (PA) is associated with a range of physical and psychological benefits among chronic disease populations. Celiac disease is a chronic autoimmune condition that requires strict adherence to a gluten-free diet (GFD) for the best medical outcomes, as well as to prevent detrimental health outcomes including bloating, diarrhea, constipation, and increased risk of intestinal cancers and osteoporosis. Despite following a GFD, individuals with celiac disease often report dissatisfaction with the diet, are less likely to engage in social activities, can have an imbalance in gut bacteria and up to 30% still report negative symptoms (e.g., gastro-intestinal upset). Furthermore, preliminary research revealed that rates of PA among those with celiac disease are dismal, with the majority of participants failing to engage in regular PA. The purpose of this pilot research project is to examine the effects of a 12-week structured exercise program on inactive adults with celiac disease. It is anticipated that compared to those in a wait-list control condition, participants who engage in the 12-week exercise program will report greater improvements in quality of life and experience improved balance of gut bacteria. The findings from this project may reveal an additional strategy to optimize health while living with celiac disease. In addition, results from this study will provide essential pilot data that will inform a grant application for a larger clinical trial to further investigate the role of exercise in the promotion of health and well-being among those with celiac disease.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Feasibility and effects on the gut microbiota of a 12-week high-intensity interval training plus lifestyle education intervention on inactive adults with celiac disease.
   Warbeck C, Dowd AJ, Kronlund L, Parmar C, et al · · 2021 · cited 17× · PMID 32961065 · DOI 10.1139/apnm-2020-0459
2. A 12-Week Pilot Exercise Program for Inactive Adults With Celiac Disease: Study Protocol.
   Dowd AJ, Kronlund L, Parmar C, Daun JT, et al · · 2019 · cited 6× · PMID 31218116 · DOI 10.1177/2164956119853777