NCT03517878 is a clinical trial of Comprehensive CHW Program in HIV Infections, sponsored by University of California, Los Angeles.

Who is sponsoring NCT03517878?

NCT03517878 is sponsored by University of California, Los Angeles.

What drugs are being tested in NCT03517878?

Interventions in NCT03517878: Comprehensive CHW Program.

What condition does NCT03517878 study?

NCT03517878 studies HIV Infections, HIV/AIDS, Depression, Depressive Symptoms, Alcohol Use Disorder, Alcohol Drinking, Stunting, Alcohol; Harmful Use, Child Development, Child Malnutrition, Child Nutrition Disorders, Birth Weight Less Than 10Th Percentile.

Is NCT03517878 still recruiting?

NCT03517878 is currently completed. Last updated 22 December 2025.

Last reviewed 2025-12-22 · How we verify

NCT03517878

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Evaluation of a Home-based Community Health Worker Program in Rural Eastern Cape, South Africa

Completed Last updated 22 December 2025

What this trial tests

trial testing Comprehensive CHW Program in HIV Infections in 1,490 participants. Completed in 1 June 2018.

Timeline

11 August 2014

Primary endpoint
1 June 2018

1 June 2018

Quick facts

Lead sponsor	University of California, Los Angeles
Status	Completed
Study type	OBSERVATIONAL
Enrollment	1,490
Start date	11 August 2014
Primary completion	1 June 2018
Estimated completion	1 June 2018
Sites	2 locations across South Africa

Drugs / interventions tested

Comprehensive CHW Program

Conditions studied

HIV Infections — all drugs for HIV Infections →
HIV/AIDS — all drugs for HIV/AIDS →
Depression — all drugs for Depression →
Depressive Symptoms — all drugs for Depressive Symptoms →

Sponsor

University of California, Los Angeles

Who can join

0 and older, any sex, with HIV Infections or HIV/AIDS. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this early Phase 2 comparison trial is to evaluate the impact of community health worker (CHW) home visitors on pregnant women and their children in a rural setting in the rural Eastern Cape of South Africa. The intervention provided by the CHWs targets underweight children, mothers living with HIV (MLH), mothers using alcohol, and depressed mothers with the goal of supporting pregnant women to improve birth outcomes, decrease the number of children born with a low birthweight, and develop child caretaking skills over time. UCLA has identified and matched four areas surrounding primary health care clinics: two intervention areas in which this CHW program has been running for one year, and two control areas without the program. Mothers in the research area are followed for one year after giving birth.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Lay health workers in primary and community health care for maternal and child health: identification and treatment of wasting in children.
Papadopoulou E, Lim YC, Chin WY, Dwan K, et al · · 2023 · cited 2× · PMID 37646367 · DOI 10.1002/14651858.cd015311

Verify or expand the search:

Other recruiting trials for HIV Infections

Currently open trials in the same condition.

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NCT06665646 — Clinical Trial to Evaluate the Safety and Immunogenicity of Hiltonol, Poly-ICLC-adjuvanted CD40.HIVRI.Env (VRIPRO) in Ad · Phase 1 · recruiting

Other University of California, Los Angeles trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03517878 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of California, Los Angeles
Last refreshed: 22 December 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03517878.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing