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NCT03513809
Inflammation and Distribution of Pulmonary Ventilation Before and After Tracheal Intubation in ARDS Patients
trial testing Thoracic electrical impedance tomography in Acute Hypoxemic Respiratory Failure in 40 participants. Status unknown.
21 March 2021
Quick facts
| Lead sponsor | Pontificia Universidad Catolica de Chile |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 40 |
| Start date | 8 June 2017 |
| Primary completion | 21 March 2021 |
| Estimated completion | 31 March 2021 |
| Sites | 1 location across Chile |
Drugs / interventions tested
- Thoracic electrical impedance tomography
Conditions studied
- Acute Hypoxemic Respiratory Failure — all drugs for Acute Hypoxemic Respiratory Failure →
- Acute Respiratory Distress Syndrome — all drugs for Acute Respiratory Distress Syndrome →
Sponsor
Pontificia Universidad Catolica de Chile — full company profile →
Who can join
18 and older, any sex, with Acute Hypoxemic Respiratory Failure or Acute Respiratory Distress Syndrome. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Spontaneous breathing efforts in patients with respiratory failure connected to mechanical ventilation, has been associated with strong respiratory muscles activity. However, these mechanisms may will be present in patients with acute lung deseases who are breathing with no ventilatory support. We hypothesize that spontaneous breathing during acute respiratory failure could induced lung inflammation and worsen lung damage. Hereby, the connection to a ventilatory support tool, may protect the lungs from spontaneous ventilation-induced lung injury. To test our hypothesis, our aim is to determine the effects of spontaneous breathing in acute respiratory failure patients, on lung injury distribution; and to determine whether early controlled mechanical ventilation can avoid these deleterious effects by improving air distribution.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Association between controlled mechanical ventilation and systemic inflammation in acute hypoxemic respiratory failure: an observational cohort study.
Bachmann MC, Benites M, Oviedo V, Vadeghani NH, et al · · 2025 · cited 3× · PMID 41219816 · DOI 10.1186/s13054-025-05727-7
Verify or expand the search:
- PubMed search for NCT03513809
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Acute Hypoxemic Respiratory Failure
Currently open trials in the same condition.
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- NCT06921655 — Targeting prEssure-Muscle-index to Avoid Ventilatory Over-Assistance During Pressure Support Ventilation · NA · recruiting
- NCT06931938 — Awake Prone Positioning in Spontaneous Breathing Patients With Acute Hypoxic Respiratory Failure Due to Pneumonia · NA · recruiting
- NCT07178483 — Evaluation of Physical Capacity and Energy Requirements in Patients With Hypoxemic Acute Respiratory Failure · active not recruiting
- NCT06815523 — Prediction of Duration of Mechanical Ventilation in Acute Hypoxemic Respiratoty Failure · active not recruiting
Other Pontificia Universidad Catolica de Chile trials
Trials by the same sponsor.
- NCT07396129 — Assessing the Efficacy of a High-Dose Lidocaine-Tetracaine Cream for the Treatment of Peripheral Neuropathic Pain · Phase 1, PHASE2 · not yet recruiting
- NCT07510425 — Artificial Intelligence vs. Automated Messaging for Continuous Regional Analgesia Follow-up · NA · not yet recruiting
- NCT07380451 — Modular Intervention for Depression Study · NA · not yet recruiting
- NCT07324499 — Effect of Dexamethasone on Plasma Levels of Bupivacaine and Dexamethasone After a Single-injection Interscalene Nerve Bl · NA · not yet recruiting
- NCT07330947 — Incidence and Risk Factors of Postoperative Chronic Pain in Patients Who Have Undergone Hallux Valgus Surgery · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03513809 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Pontificia Universidad Catolica de Chile
- Last refreshed: 10 March 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03513809.
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