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NCT03513705: PACAP-1
Impact of Nationwide Enhanced Implementation of Best Practices in Pancreatic Cancer Care (PACAP-1)
NA trial testing Best practices in pancreatic cancer care in Carcinoma, Pancreatic Ductal in 4,000 participants. Completed in 9 July 2021.
9 July 2020
Quick facts
| Lead sponsor | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 4,000 |
| Start date | 22 May 2018 |
| Primary completion | 9 July 2020 |
| Estimated completion | 9 July 2021 |
| Sites | 17 locations across Netherlands |
Drugs / interventions tested
- Best practices in pancreatic cancer care
Conditions studied
- Carcinoma, Pancreatic Ductal — all drugs for Carcinoma, Pancreatic Ductal →
Sponsor
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) — full company profile →
Who can join
Eligibility, any sex, with Carcinoma, Pancreatic Ductal. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
PACAP-1 will evaluate to what extent an enhanced implementation of best practices in pancreatic cancer care leads to a prolonged survival and improvement of quality of life as compared to current practice.
Publications & conference data
5 peer-reviewed publications reference this trial (live from Europe PMC):
-
Irreversible Electroporation and Nivolumab Combined with Intratumoral Administration of a Toll-Like Receptor Ligand, as a Means of In Vivo Vaccination for Metastatic Pancreatic Ductal Adenocarcinoma (PANFIRE-III). A Phase-I Study Protocol.
Geboers B, Timmer FEF, Ruarus AH, Pouw JEE, et al · · 2021 · cited 29× · PMID 34359801 · DOI 10.3390/cancers13153902 -
Implementation of Best Practices in Pancreatic Cancer Care in the Netherlands: A Stepped-Wedge Randomized Clinical Trial.
Mackay TM, Latenstein AEJ, Augustinus S, van der Geest LG, et al · · 2024 · cited 19× · PMID 38353966 · DOI 10.1001/jamasurg.2023.7872 -
Impact of nationwide enhanced implementation of best practices in pancreatic cancer care (PACAP-1): a multicenter stepped-wedge cluster randomized controlled trial.
Mackay TM, Smits FJ, Latenstein AEJ, Bogte A, et al · · 2020 · cited 18× · PMID 32299515 · DOI 10.1186/s13063-020-4180-z -
Quality of Life Among Patients With Locally Advanced Pancreatic Cancer: A Prospective Nationwide Multicenter Study.
Seelen LWF, Augustinus S, Stoop TF, Bouwense SAW, et al · · 2025 · cited 3× · PMID 39970867 · DOI 10.6004/jnccn.2024.7091 -
Nationwide implementation of the international multidisciplinary best-practice for locally advanced pancreatic cancer (PREOPANC-4): study protocol.
Stoop TF, Seelen LWF, van 't Land FR, van der Hout AC, et al · · 2025 · cited 2× · PMID 39972248 · DOI 10.1186/s12885-025-13554-w
Verify or expand the search:
- PubMed search for NCT03513705
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Currently open trials in the same condition.
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Other Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03513705 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
- Last refreshed: 16 August 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03513705.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing