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NCT03511651
The Effect of Positive End-Expiratory Pressure on Functional Residual Capacity During Mechanical Ventilation
NA trial testing PEEP in Mechanical Ventilation in 30 participants. Status unknown.
28 February 2021
Quick facts
| Lead sponsor | Capital Medical University |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | quadruple |
| Primary purpose | other |
| Enrollment | 30 |
| Start date | 1 August 2020 |
| Primary completion | 28 February 2021 |
| Estimated completion | 31 March 2021 |
| Sites | 1 location across China |
Drugs / interventions tested
- PEEP
Conditions studied
- Mechanical Ventilation — all drugs for Mechanical Ventilation →
- Acute Respiratory Distress Syndrome — all drugs for Acute Respiratory Distress Syndrome →
- Functional Residual Capacity — all drugs for Functional Residual Capacity →
Sponsor
Capital Medical University
Who can join
Adults 18 to 80, any sex, with Mechanical Ventilation or Acute Respiratory Distress Syndrome. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Although positive end-expiratory pressure (PEEP) has been widely used in mechanical ventilated patients with acute respiratory distress syndrome (ARDS), how to select the "optimal" PEEP is far from consensus. The application of PEEP may result in beneficial effect by recruiting previously collapsed lung areas, harmful effect by over-distending previously aerated lung areas, or a combination of the both. The net effect of PEEP in a certain patient may depend on the recruitability. Because recruitability varies extremely in ARDS patients and strongly correlates with the response to PEEP, estimation of end-expiratory lung volume (EELV) may be essential for individualized setting of PEEP. Whether the FRC changes at different PEEP levels remains unknown.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT03511651
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Related trials
Other trials of PEEP
Trials testing the same drug.
- NCT06654778 — Ultrasound Evaluation of Preventive Measures for Postoperative Lung Atelectasis After Surgery · NA · completed
- NCT06270485 — Influence of Positive-End-Expiratory-Pressure (PEEP) on Cardiac Output in Mechanically Ventilated Children · NA · completed
- NCT05691205 — Identifying Optimal PEEP After Lung Transplantation · NA · completed
- NCT05275283 — Efficacy Evaluation of Positive End-expiratory Pressure in Children Undergoing Mechanical Ventilation Using Supraglottic · NA · unknown
- NCT04853563 — Comparison of PEEP in Acute Decompensated Heart Failure · NA · unknown
Other recruiting trials for Mechanical Ventilation
Currently open trials in the same condition.
- NCT07467551 — Turkish Validity and Reliability of the Behavioral Indicators of Pain Scale(ESCID) · NA · recruiting
- NCT07430111 — Flow-Controlled Versus Volume-Controlled Ventilation in Bariatric Surgery · NA · recruiting
- NCT07361419 — Metabolic Response to Supine Physiotherapy in Mechanically Ventilated ICU Patients · active not recruiting
- NCT06994442 — Optimizing Pain Treatment in Children On Mechanical Ventilation · Phase 3 · recruiting
- NCT07193719 — Influence of Personalized Lung Volume Optimization Maneuver on Lung Function and Cardiac Performance in Children · Phase 1, PHASE2 · recruiting
Other Capital Medical University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03511651 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Capital Medical University
- Last refreshed: 29 May 2020
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