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NCT03510793
Microcirculation and Anesthesia in Vascular Surgery
trial testing balanced anesthesia in Ischemia Reperfusion Injury in 40 participants. Completed in 30 November 2017.
30 November 2017
Quick facts
| Lead sponsor | Università Politecnica delle Marche |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 40 |
| Start date | 1 September 2013 |
| Primary completion | 30 November 2017 |
| Estimated completion | 30 November 2017 |
Drugs / interventions tested
- balanced anesthesia — full drug profile →
- Total intravenous anesthesia
Conditions studied
- Ischemia Reperfusion Injury — all drugs for Ischemia Reperfusion Injury →
- Aortic Aneurysm — all drugs for Aortic Aneurysm →
- Anesthesia — all drugs for Anesthesia →
Sponsor
Università Politecnica delle Marche — full company profile →
Who can join
18 and older, any sex, with Ischemia Reperfusion Injury or Aortic Aneurysm. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Ischemia/reperfusion injury following aortic cross-clamping for vascular surgery leads to systemic hemodynamic and microcirculatory perturbances. The use of different anesthetic regimens may have an impact on tissue perfusion. The aim of this study was to explore changes in microvascular perfusion in patients undergoing elective open abdominal aortic aneurysm repair under balanced or total intravenous anesthesia. Prospective observational study on 40 patients scheduled for elective open infrarenal abdominal aortic aneurysm repair, who received balanced (desflurane + remifentanil, n=20) or total intravenous anesthesia (TIVA, propofol + remifentanil using target-controlled infusion, n=20) according to the clinician's decision. A goal-directed hemodynamic management was applied in all patients. Hemodynamics and arterial/venous blood gases were compared before anesthesia induction (baseline) and at end-surgery. Changes in sublingual microvascular flow and density were assessed with incident dark field illumination imaging. Near infrared spectroscopy was applied on the thenar eminence with a vascular occlusion test (VOT) to assess variations in the peripheral muscle tissue oxygenation and microcirculatory reactivity.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Changes in the sublingual microcirculation following aortic surgery under balanced or total intravenous anaesthesia: a prospective observational study.
Loggi S, Mininno N, Damiani E, Marini B, et al · · 2019 · cited 10× · PMID 30611197 · DOI 10.1186/s12871-018-0673-7
Verify or expand the search:
- PubMed search for NCT03510793
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Università Politecnica delle Marche trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03510793 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Università Politecnica delle Marche
- Last refreshed: 3 May 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03510793.
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