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NCT03510650
Diagnostic Biomarkers for Adult Hemophagocytic Lymphohistiocytosis in Critically Ill Patients (HEMICU)
trial in Hemophagocytic Lymphohistiocytosis in 100 participants. Completed in 26 December 2022.
26 June 2022
Quick facts
| Lead sponsor | Charite University, Berlin, Germany |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 100 |
| Start date | 11 September 2018 |
| Primary completion | 26 June 2022 |
| Estimated completion | 26 December 2022 |
| Sites | 1 location across Germany |
Conditions studied
- Hemophagocytic Lymphohistiocytosis — all drugs for Hemophagocytic Lymphohistiocytosis →
Sponsor
Charite University, Berlin, Germany
Who can join
Adults 18 to 100, any sex, with Hemophagocytic Lymphohistiocytosis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Hemophagocytic lymphohistiocytosis in adults (HLH) is at 68% mortality whereas 78% of all cases remain undiagnosed though therapies are available which clearly reduce mortality. The investigators aim to systematically investigate this life-threatening hyperinflammatory syndrome in intensive care units (ICU) in order to detect biomarkers that are highly sensitive and highly specific for HLH in ICU compared to patients with sepsis.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Macrophage Activation-Like Syndrome: A Distinct Entity Leading to Early Death in Sepsis.
Karakike E, Giamarellos-Bourboulis EJ. · · 2019 · cited 223× · PMID 30766533 · DOI 10.3389/fimmu.2019.00055 -
Diagnostic biomarkers for adult haemophagocytic lymphohistiocytosis in critically ill patients (HEMICU): a prospective observational study protocol.
Lachmann G, Knaak C, von Haefen C, Paeschke N, et al · · 2019 · cited 8× · PMID 31666276 · DOI 10.1136/bmjopen-2019-032695
Verify or expand the search:
- PubMed search for NCT03510650
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03510650 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Charite University, Berlin, Germany
- Last refreshed: 4 January 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03510650.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing