NCT03510182

Transcranial Direct Current Stimulation (tDCS) and Intensive Therapy in Aphasia

Completed NA Results posted Last updated 20 September 2021

What this trial tests

NA trial testing transcranial direct current stimulation in Aphasia in 25 participants. Completed in 26 February 2020.

Timeline

15 December 2016

Primary endpoint
26 February 2020

26 February 2020

Quick facts

Lead sponsor	University of Michigan
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	25
Start date	15 December 2016
Primary completion	26 February 2020
Estimated completion	26 February 2020
Sites	1 location across United States

Drugs / interventions tested

• transcranial direct current stimulation

Conditions studied

• Aphasia — all drugs for Aphasia →

Sponsor

University of Michigan

Who can join

18 and older, any sex, with Aphasia. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Change in Controlled Oral Word Fluency Primary · baseline and 4 weeks

This test assesses the number of words that can be generated in one minute that begin with certain letters. The total number of words generated for three letters is derived. Higher scores represent better performance. Changes in word fluency were calculated as follows: number of words generated post tDCS minus number of words generated pre tDCS

Group	Value	95% CI
Transcranial Direct Current Stimulation	3.1	± 4.89

Change in Boston Naming Score Primary · baseline and 4 weeks

This test assesses confrontational naming ability to 60 line drawings. Scores range from 0-60 with higher scores representing better performance. Outcome was derived as followed : Picture naming score post tDCS minus picture naming score pre tDCS

Group	Value	95% CI
Transcranial Direct Current Stimulation	1.25	± 3.96

Change in Western Aphasia Quotient Score Secondary · baseline and 4 weeks

severity of aphasia is measured by the Western Aphasia Battery Revised. The Aphasia Quotient (AQ) score ranges from 0-100, with 100 being a perfect score. Change in the AQ was derived as follows : AQ post tDCS minus AQ pre tDCS

Group	Value	95% CI
Transcranial Direct Current Stimulation	8.57	± 6.37

Sponsor's own description

Intensive therapy for aphasia has been demonstrated to improve language functioning after stroke or other neurological injury. However, recovery is generally not complete and new therapies are needed to improve outcomes. Transcranial direct current stimulation (tDCS) has been shown to improve outcomes with motor therapy after stroke. This study will examine the feasibility of using tDCS with intensive language therapy as a way of enhancing language outcomes in aphasia

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.