NCT03504215

Exercise Intervention to Rescue the Adverse Effect of Preterm Birth on Cardiovascular and Pulmonary Health.

Completed NA Last updated 3 November 2022

What this trial tests

NA trial testing Exercise Intervention in Prematurity; Extreme in 68 participants. Completed in 27 January 2021.

Timeline

2 March 2018

Primary endpoint
18 January 2021

27 January 2021

Quick facts

Lead sponsor	St. Justine's Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	prevention
Enrollment	68
Start date	2 March 2018
Primary completion	18 January 2021
Estimated completion	27 January 2021
Sites	1 location across Canada

Drugs / interventions tested

• Exercise Intervention

Conditions studied

• Prematurity; Extreme — all drugs for Prematurity; Extreme →

Sponsor

St. Justine's Hospital

Who can join

Adults 18 to 29, any sex, with Prematurity; Extreme. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In spite of advances in neonatal intensive care allowing the first generation survivors of extreme prematurity to now reach young adulthood, these individuals present with reduced exercise capacity; a strong predictor of later chronic disease and mortality. The reason why individuals born preterm have exercise limitation remains unclear and may be a consequence of impact of preterm birth and associated neonatal difficulties on the development of organs important for exercise, namely the lungs, the heart, the vessels (which bring blood and oxygen to the muscles) and the muscles. It is well known that exercise benefits overall health in at-risk as well diseased populations. However, whether exercise training can improve fitness in young adults born preterm was not demonstrated and whether the cardiovascular, pulmonary and muscle impairments associated with preterm birth are reversible through exercise intervention in young adulthood is unknown.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. HAPI Fit: An Exercise Intervention to Improve Peak Aerobic Capacity in Young Adults Born Very Preterm.
   Tardif CB, Mathieu ME, Caru M, Al-Simaani A, et al · · 2024 · cited 5× · PMID 37707478 · DOI 10.1249/mss.0000000000003279
2. Clinical study: Cardiovascular outcomes after a 14-week exercise intervention in young adults born preterm.
   Girard-Bock C, Michaud C, Dartora DR, Al-Simaani A, et al · · 2026 · PMID 42236922 · DOI 10.1038/s41390-026-05130-0