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NCT03504176
Pediatric Acute Respiratory Distress Syndrome Ventilation Bundle
trial testing Ventilation bundle in Acute Respiratory Distress Syndrome in 134 participants. Completed in 12 May 2020.
12 May 2020
Quick facts
| Lead sponsor | KK Women's and Children's Hospital |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 134 |
| Start date | 6 April 2018 |
| Primary completion | 12 May 2020 |
| Estimated completion | 12 May 2020 |
| Sites | 1 location across Singapore |
Drugs / interventions tested
- Ventilation bundle
Conditions studied
- Acute Respiratory Distress Syndrome — all drugs for Acute Respiratory Distress Syndrome →
Sponsor
KK Women's and Children's Hospital
Who can join
Under 21, any sex, with Acute Respiratory Distress Syndrome. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Mortality rates in children with pediatric acute respiratory distress syndrome (PARDS) are higher in Asia compared to other regions. In adults with acute respiratory distress syndrome, the only therapy that improves mortality rates is a lung protective ventilation strategy. The pediatric ventilation recommendations by the Pediatric Acute Lung Injury Consensus Conference (PALICC) are extrapolated from evidence in adults, including ventilation with low tidal volume, low peak/plateau pressures and high end expiratory pressure. A recent retrospective study of ventilation practices in Asia including Singapore showed that a majority of patients with PARDS were being ventilated with high tidal volume, high peak pressure and low end expiratory pressure, not in compliance with PALICC recommendations. We postulate that currently used ventilation strategies could have contributed to the high PARDS mortality rates in Asia. We aim to determine if implementing a ventilation bundle comprising PALICC recommendations lowers PARDS and pediatric intensive care unit (PICU) mortality rates.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Care bundles for improving outcomes in patients with COVID-19 or related conditions in intensive care - a rapid scoping review.
Smith V, Devane D, Nichol A, Roche D. · · 2020 · cited 11× · PMID 33348427 · DOI 10.1002/14651858.cd013819
Verify or expand the search:
- PubMed search for NCT03504176
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Acute Respiratory Distress Syndrome
Currently open trials in the same condition.
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- NCT07289711 — Validation and Precision Treatment of Inflammatory Subphenotypes in Acute Respiratory Distress Syndrome: A Multicenter C · recruiting
- NCT07326215 — A Study of the Efficacy and Safety of Extracorporeal Carbon Dioxide Removal Using PrismaLung+ · NA · recruiting
- NCT06919484 — The Physiological Effect of RCexp on Ventilation/Perfusion Distribution · recruiting
- NCT07126964 — Extended Prone Positioning for Intubated ARDS · NA · recruiting
Other KK Women's and Children's Hospital trials
Trials by the same sponsor.
- NCT07534670 — Early Pregnancy Lifestyle and Glucose Patterns: A Substudy of TOFFFY · NA · not yet recruiting
- NCT07466797 — The eHealth Integrated Maternal Physical Activity Programme in Prenatal Care Trial (E-IMPACT) · NA · recruiting
- NCT06457750 — Anthropometric Outcomes of a Mobile Health Intervention for Eating Behaviour and Lifestyle in Infancy · NA · not yet recruiting
- NCT06481644 — Asia Pediatric Intensive Care Epidemiology and Outcomes Study · recruiting
- NCT06489834 — Group Drumming for Improving the Health of Community-Dwelling Elderly · NA · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03504176 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by KK Women's and Children's Hospital
- Last refreshed: 20 May 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03504176.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing