NCT03500003: FermentoMilk

Metabolic Signatures of Dairy Products Ingestion in Humans: Effect of Age

Completed NA Last updated 7 August 2019

What this trial tests

NA trial testing Acute milk intake in Nutrition in 28 participants. Completed in 6 August 2019.

Timeline

1 June 2018

Primary endpoint
6 August 2019

6 August 2019

Quick facts

Lead sponsor	Sergio Polakof
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	basic science
Enrollment	28
Start date	1 June 2018
Primary completion	6 August 2019
Estimated completion	6 August 2019
Sites	1 location across France

Drugs / interventions tested

• Acute milk intake
• Acute Yogurt intake

Conditions studied

• Nutrition — all drugs for Nutrition →

Sponsor

Sergio Polakof

Who can join

Adults 25 to 80, male only, with Nutrition. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Despite the fact that dairy products are greatly consumed, it remains today very difficult to determine with a classical blood biochemical test whether a person has ingested a fresh fermented dairy product or just milk, while their biological, metabolic and health impacts may be different.

The metabolic footprint left by the consumption of these products could be modified by the age of the consumer. Indeed, in the elderly, the processes of digestion, assimilation and metabolism are known to be altered /different compared to healthy adults. Thus, different metabolic signatures in the elderly could appear as the result of a less effective use and metabolism of the nutrients ingested. This could further also result in different or altered biological effects on dairy products.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

1. Postprandial Responses on Serum Metabolome to Milk and Yogurt Intake in Young and Older Men.
   Kim J, Blaser C, Portmann R, Badertscher R, et al · · 2022 · cited 7× · PMID 35600812 · DOI 10.3389/fnut.2022.851931
2. Microbiota and Metabolite Modifications after Dietary Exclusion of Dairy Products and Reduced Consumption of Fermented Food in Young and Older Men.
   Kim J, Burton-Pimentel KJ, Fleuti C, Blaser C, et al · · 2021 · cited 6× · PMID 34205926 · DOI 10.3390/nu13061905
3. Postprandial metabolic effects of milk and yoghurt in young and older adults.
   Hillesheim E, Lépine G, Neuhaus P, Burton-Pimentel KJ, et al · · 2025 · PMID 41084093 · DOI 10.1186/s12263-025-00780-x