Last reviewed · How we verify
NCT03499678
Lung Cancer Screening Using DNA Methylation Changes in Circulated Tumor and PBMC DNA
trial in Lung Cancer in 81 participants. Terminated before completion.
19 July 2019
Quick facts
| Lead sponsor | HKGepitherapeutics |
|---|---|
| Status | Terminated |
| Study type | OBSERVATIONAL |
| Enrollment | 81 |
| Start date | 1 July 2018 |
| Primary completion | 19 July 2019 |
| Estimated completion | 19 July 2019 |
| Sites | 1 location across Kazakhstan |
Conditions studied
- Lung Cancer — all drugs for Lung Cancer →
- Lung Cancer, Nonsmall Cell — all drugs for Lung Cancer, Nonsmall Cell →
- Lung Cancer, Small Cell — all drugs for Lung Cancer, Small Cell →
Sponsor
HKGepitherapeutics
Who can join
18 and older, any sex, with Lung Cancer or Lung Cancer, Nonsmall Cell. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A central challenge in the fight against lung cancers is how to detect disease in a noninvasive manner before it is detectable by imaging methods. Although inroads have been made with more sensitive imaging techniques for earlier detection of breast and lung cancers, these techniques are limited by the size of lesion that could be detected. Alternatively, several blood proteomic biomarkers have been proposed but none offer as of yet sufficient predictive power. Consequently, effective non-invasive tools as prognostic indicators and biomarkers of lung cancer is urgently needed. The purpose of this study is to develop and test non-invasive biomarkers based on methylation changes in PBMC and circulated tumor DNA in lung cancer patients.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Exploring the Potential of Non-Coding RNAs as Liquid Biopsy Biomarkers for Lung Cancer Screening: A Literature Review.
Garbo E, Del Rio B, Ferrari G, Cani M, et al · · 2023 · cited 11× · PMID 37835468 · DOI 10.3390/cancers15194774
Verify or expand the search:
- PubMed search for NCT03499678
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other HKGepitherapeutics trials
Trials by the same sponsor.
- NCT03734419 — The Use of Aging Biomarkers in Saliva, Based on DNA Methylation Status in Elovl2 to Predict Biological Age · withdrawn
- NCT03483922 — HCC Screening Using DNA Methylation Changes in ctDNA · completed
- NCT03494803 — Detection of Prostate Cancer With Non-invasive Method Based on DNA Methylation of Circulated Tumor DNA, PBMC · withdrawn
- NCT03480659 — Detection of Breast Cancer With Non-invasive Method Based on DNA Methylation of Circulated Tumor DNA, PBMC · terminated
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03499678 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by HKGepitherapeutics
- Last refreshed: 22 December 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03499678.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing