NCT03498885 (PLAND) is a NA clinical trial of Low ligation in Rectal Cancer, sponsored by WEIDONG LIU，MD.

Who is sponsoring NCT03498885?

NCT03498885 is sponsored by WEIDONG LIU，MD.

What drugs are being tested in NCT03498885?

Interventions in NCT03498885: Low ligation, High ligation.

What condition does NCT03498885 study?

NCT03498885 studies Rectal Cancer.

Is NCT03498885 still recruiting?

NCT03498885 is currently status unknown. Last updated 9 September 2020.

Last reviewed 2020-09-09 · How we verify

NCT03498885: PLAND

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparison of Low and High Ligation With Apical Lymph Node Dissection in the Laparoscopy Rectal Cancer

Status unknown NA Last updated 9 September 2020

What this trial tests

NA trial testing Low ligation in Rectal Cancer in 466 participants. Status unknown.

Timeline

1 January 2018

Primary endpoint
1 December 2022

1 December 2025

Quick facts

Lead sponsor	WEIDONG LIU，MD
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	466
Start date	1 January 2018
Primary completion	1 December 2022
Estimated completion	1 December 2025
Sites	1 location across China

Drugs / interventions tested

Low ligation
High ligation

Conditions studied

Rectal Cancer — all drugs for Rectal Cancer →

Sponsor

WEIDONG LIU，MD

Who can join

Adults 18 to 75, any sex, with Rectal Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to explore the different impacts of high and low ligation in laparoscopic rectal interior resection on postoperative anastomotic leakage and proximal bowel necrosis and stenosis, as well as the quality of life and long-term survival. In the anterior resection of rectum, the section level of inferior mesenteric artery (IMA) is still a controversial subject between the advocates of high and low ligation. The low ligation is defined as the IMA is ligated below the origin of the left colic artery while the high ligation refers to the IMA is ligated at its origin from the aorta. Nowadays the spread of laparoscopy has encouraged more frequent execution of the high ligation, which appears easier to achieve than the low ligation and also with the advantage of lower anastomosis traction but with the disadvantage of worse vascularization of the stumps as well.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

To go high, or to go low: the never-ending debate of inferior mesenteric artery ligation.
Baik H. · · 2024 · cited 3× · PMID 38325809 · DOI 10.3393/ac.2024.00094.0013

Verify or expand the search:

Other recruiting trials for Rectal Cancer

Currently open trials in the same condition.

NCT07528209 — Neoadjuvant CAPOX With or Without Pucotenlimab Plus Selective Radiotherapy for Locally Advanced Rectal Cancer · Phase 3 · recruiting
NCT07537998 — Antegrade Intestinal Fluid Reinfusion for Prevention of Low Anterior Resection Syndrome After Low Anterior Resection: a · Phase 2, PHASE3 · recruiting
NCT07501845 — Registry Maastro Applicator · recruiting
NCT07369531 — The Impact of Two-Stage Turnbull-Cutait Pull-Through Coloanal Anastomosis on Stoma-free Survival in Low Rectal Anal-pres · NA · recruiting
NCT07505472 — Efficacy and Safety Comparison of Short-course Radiotherapy Followed by CapeOX Chemotherapy Plus Toripalimab With or Wit · Phase 2, PHASE3 · recruiting

Other WEIDONG LIU，MD trials

Trials by the same sponsor.

NCT04302363 — Analysis of Intestinal Microflora Combined With DNA Methylation in Stool to Detect Colorectal Cancer · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03498885 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by WEIDONG LIU，MD
Last refreshed: 9 September 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03498885.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing